Effect of Aqueous Leaf Extract of Neem (Azadirachta indica) on the Hormonal Milieu of Male Rats
The effects of aqueous leaf extract of neem on serum testosterone, follicle stimulating hormone (FSH), luteinizing hormone/interstitial cell stimulating hormone (LH/ICSH), estrogen and prolactin levels in male albino rats were studied. Rats treated with 50, 100 and 150 mg/kg body weight of neem extract intraperitoneally daily for 15 days showed very highly significant (P< 0.001) reduction effects on serum concentration of testosterone, FSH, LH/ICSH and prolactin when compared with their control counterparts. On the other hand, the aqueous leaf extract of neem had a very highly significantly (P<0.001) increasing effect on serum concentration of estradiol. There were dose-dependent effects of the aqueous leaf extract of neem on the serum concentration of the hormones. These observations suggest that the aqueous leaf extract of neem had strong anti-androgenic property and capability to disrupt hormonal functions. Hence, its indiscriminate use in malaria chemotherapy could increase the in risk of infertility in males.