Objective of This study to evaluated the time elapsed between bone scan and chemotherapy dose. Bone scan is the accepted initial imaging modality for skeletal metastases. Some patients use chemotherapy in the initial stages before and after surgery for breast cancer patients According to the international protocol followed, and in our study, it is used to give patients chemotherapy compounds for several cycle and medicines used in the study are and to determine the duration of this effect. The most common drugs used for adjuvant and nanadjuvant chemotherapy. Include: Anthracyclines, such as doxorubicin (Adriamycin) and epirubicin (Ellence) Taxanes, such as paclitaxel (Taxol) and docetaxel (Taxotere) 5-fluorouracil (5-FU) Cyclophosphamide (Cytoxan) Carboplatin (Paraplatin)(1) some chemotherapy regimens. Knowing that platinum reacts with phosphate compounds such as methylenediphosphonic acid (MDP), decreases bone absorption and new bone formation, it can be proposed that chemotherapy may decrease Tc-99m MDP bone uptake. We aimed to demonstrate, if present, the decrease in bone uptake with the possibility of the effect of chemotherapy on the weakness of blood flow to the entry of radiopharmaceutical material to the bone cells and their effect on the oesteablast.
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