Comparison of effects of sodium bicarbonate and normal saline mouthwash for management of radiation induced mucositis in patients undergoing radiation for oropharyngeal cancer

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Author: 
Dr. Arunkumar, C., Dr. Srinivasan, V., Dr. Balaji, N. and Dr. Indumathi, G.
Subject Area: 
Health Sciences
Abstract: 

Background: Oral Carcinoma is the 6th most common carcinoma worldwide and Radiotherapy is the one among the treatment option. Oral care is the most important option to combat complication due to radiation, in oral cancer. Sodium bicarbonate mouth rinse is better than normal saline in relieving side effects. Aim: To compare the effects of sodium bicarbonate and normal saline in reducing radiation induced side effects Methods: A total of 73 patients undergoing radiation for head and neck cancer were selected. Among them, 36 patients (Including 19 males and 17 Females) were allowed to gargle with normal saline and remaining 37 patient (Including 20 Males and 17 Females) were given sodium bi carbonate for mouth gargles. They were looked for radiation induced side effects in 2 weeks period and 4week period. The data were recorded and analyzed. Results: Results were analysed with spss version 16 software and statistical test used: chi square and fisher exact test Conclusion: Sodium bicorbonate mouthwash during radiation therapy for oral cancer is better than saline mouthwash in reducing severity of radiation induced mucositis.

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