Osteoarthritis of the knee is a common cause of pain, reduced mobility and quality of life (QOL) in adults. People with knee osteoarthritis experience restricted participation in activities and behaviors of their choice, and thus it affects their social life. Given the increasing incidence of symptomatic knee Osteoarthritis and the role of non-pharmacological interventions in mitigating symptoms, it is important to find low-cost, easy to administer interventions. The purpose of this study was to investigate the effect of therapeutic exercises on knee related pain, QOL and mobility by following KOOS, timed up and go test. The results of the present study imply that therapeutic exercises that included warm-up, active range of motion exercise, strengthening exercise, muscle stretching and cool down were effective over conventional therapies that included hot packs and isometric quadriceps exercise in improving the knee related pain, QOL and mobility of middle aged adults with knee osteoarthritis.