The objectives of our study was to evaluate the efficacy, safety and tolerability of transdermal diclofenac sodium patch for in the management of postoperative pain following surgical removal of impacted mandibular third molars. Material and method: 100 healthy subjects belonging to both the sexes in the age group of 18–40 years with impacted third molar teeth were included in the study. 60 minutes before extraction, Transdermal patch of Diclofenac sodium 100mg (Diclo-patch) was applied. Subsequently surgical removal of impacted tooth was done under local anesthesia after administering the nerve block and patient was asked to change patch every 24 hours for the next 3 days. The postoperative pain was recorded on The Visual Analog Scale (VAS), Verbal Rating Scale (VRS), Pain Intensity Scale (PIS), Pain Relief Scale (PRS). Any adverse effects were also noted. Readings were taken at 4hours, 6hours, 8hours, 12hours and 24 hours postoperatively, taking the time at which the surgery was completed as a reference. Participants were given Diclofenac Sodium Transdermal Patch 100mg once a day for 3 days after performing surgery followed by follow up of 2days. Results: The statistical analysis was done using chi-square test and clinical observation revealed that on the first postoperative day significant relationship was somewhat less when diclofenac sodium administered transdermally. Though, on the second and third postoperative days there was no statistical or clinical difference in the pain control by this route of administration and found to be most effective in almost all patients whereas was even easy acceptable by them. Conclusion: The study concludes that transdermal diclofenac sodium can be used as an alternative form of pain control following removal of impacted mandibular third molars, however considering that the analgesic potency might be lesser in the immediate postoperative period in sensitive and anxious patients.