Background: Oral and dental health are a fundamental part of public health and the proper health behaviors and attitudes are necessary for health correlated workings. It depends on the person recognition and his behavior. Attitudes usually reveal his experiences, familial beliefs, culture and other life conditions that have an effect on oral health behavior. Aim of the study: The present study was designed for evaluating the influence of oral health awareness on periodontal disease status among university non dental students in King Khalid University. Methodology: Three hundred university, non dental students were selected in this study and they were divided according to their selected colleges into three equal groups Humanities, Engineering and Sciences. They completed the questionnaire of the present study during a personal interview. Plaque index (PLI), gingival index (GI), periodontal pocket depth (PPD), and clinical attachment loss (CAL) were recorded. The data were collected and analyzed by means of computerized SPSS statistical package. Results: All the patients completed the study uneventfully. Participants showed poor knowledge of causes, signs, symptoms, and preventive measures of gum disease; there were significance differences between our study groups (p 0.05) and there were significance differences between the first level and final level an almost of the participants of our study groups (p 0.05). In periodontal examination there was statistically significant differences in all the periodontal parameters in the comparison between all groups of the present study and harmonious with their oral hygiene knowledge. Conclusion: There were significant differences in oral health awareness related periodontal disease and status among non dental students in King Khalid University in different levels of studies and different specialist.