The participation of the full 9 stepped cycle of proton conductancein the translocation of electrons and protons produced during glycolysis to mitochondrial matrix

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Author: 
Ambaga, M. and Tumen-Ulzii, A.
Subject Area: 
Health Sciences
Abstract: 

The creation of normal condition of translocation of electrons and protons produced during glycolysis to mitochondrial matrix, owing to the full 9 stepped cycle of proton conductance (Ambaga and Tumen-Ulzii, 2016) have been played a more important role in the general bioenergetic processes of organism by participating to formation of proton gradients and thereby increasing the ATP generation and heat energy. In such way, any forms of deficiency of generation of the high-energy molecules as NADH, in which have been contained electrons and protons produced during glycoly sis would be lead to decrease of proton gradients, thereby limitation of cellular energy sources as ATP and heat energy. The normal condition of translocation of electrons and protons produced during glycolysisis connected with malate-aspartate shuttle is a biochemical system for translocating of protons with electrons across the semipermeable inner membrane of the mitochondrion for oxidative phosphorylation in eukaryotes. We came to conclusion that one of very useful condition of prevention of shortage of cellular energy sources, in which have been participated NADH molecules produced during glycolysisis the stimulation of the full 9 stepped cycle of proton conductance (Ambaga and Tumen-Ulzii 2016), thereby making the possibility to the intensification of anaerobic respiration and paralleled intensifying of aerobic respiration with oxygen, which would be appeared as increasing of the translocation of a electrons and protons from cytosol (contained in the NADH molecules) to mitochondrial matrix through inner mitochondrial membrane with involvement of intensified malate-aspartate shuttle.

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