Atherosclerosis is the hardening and narrowing of the arteries and is caused by the slow build-up of plaque inside the walls of arteries. The clinical manifestations of atherosclerosis include myocardial infarction, stroke and sudden cardiac death. The prevalence of the disease is high, and approximately 50% of all deaths globally can be attributed to atherosclerosis. The concept of Dusumate Dam in Unani literature has been considered responsible for the development of Salabate Sharaeen (atherosclerosis) and Simane Mufrit (obesity). A randomized, single-blind, standard controlled clinical trial was conducted in National Institute of Unani Medicine Hospital Bangalore, with the objective of evaluating the efficacy of Badranjboya (Nepeta hindostana) as a cardio-protective drug. A total of 30 patients with risks of atherosclerosis were selected randomly and assigned into two groups 20 in test and 10 in control groups. Test group was treated with Badranjboya powder, 6 grams twice a day for 2 months whereas control group was treated with Garlic powder, 2 grams powder filled in gelatin capsules and given in to two divided doses for the same duration. The response was evaluated by the assessment of subjective parameters (palpitation, breathlessness, headache and chest pain) and objective parameter (blood pressure, lipid profile, haematocrit value and random blood sugar). The data was tabulated and analyzed by using apropriate statistical tests. Test group showed significant reduction in subjective parameters (p<0.01) and objective parameters like blood pressure, MDA concentration, whereas significant increase in HDL level (p<0.01) but changes in serum cholesterol, triglyceride, LDL, and haematocrit values were found statistically not significant in both groups. The effect of the drug was prominent on vessels wall. The overall improvement in test group was highly remarkable, without any clinically and statistically significant side effects or toxicity. Therefore, it can be concluded that Badranjboya has encouraging potential in the prevention of atherosclerosis and it may be combined with other treatment modalities like weight control in obese, physical therapy and dietary modification etc. for optimal results.