Study comparison effect of a new naproxen modulated by addition of active group and a naproxen on the gastrointestinal safety and analgesic efficacy in male mice

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Author: 
Adnan. M Jassim, Sadiaq, A. Almansory, Sohaad J. Hadi, Ghasson A. Alkareem
Subject Area: 
Health Sciences
Subject Area: 
Special Issue
Abstract: 

The first step of the research is the synthesis of a new agent derived from This is done by its conversion into phenyl hydrazine. At this point a number of products may be derived; addition of fructose results in the formation of X23, addition of D-ribose results in the formation of X3, whilst addition of C6H5CHO results in the formation of F57. Furthermore, addition of NaOH produces X2) Our study set out to investigate the analgesic activity of Naproxen (20 mg/kg body weight) and to compareit toa newly modified compound of naproxen by the addition of a chemical group. Analgesic activity done by use of hot plate. Healthy male albino mice (25-30 g) were obtained from animal houses (??) in groups of six in polypropylene cages. After adaptation the mice were randomly divided into six groups (six rats in each group) Group 1labeled as the control group, was given distilled water only, whilst mice from group 2 where given naproxen and 7-6(?? you mean 3-5) given new drugs. Modified naproxen compounds and naproxen drugs significantly (p<0.001) increase analgesic time per second (pain reflex) when compared to control. The Hot plate test useful in the elucidating centrally mediated ant nociceptive responses, which focused mainly on changes above the spinal cord level. All the test and standard drugs significantly (p<0.001) reduced the pain as compare to the control group. The results of pharmacological tests performed in the present studies suggest that all new drugs possess potent analgesic activity. The second aim of our study was to carry out an investigation on the effect of new drugs(you mean the modified naproxen drugs?) on gastric tissue, the result show mice administer with X3 showed less ulcerative effect than naproxen by decrease acidity, and increase gastric juice than naproxen (do you mean; by decreasing acidity and increasing gastric juice as compared to naproxen). This finding may be grounds for further future research. (Examination of the existence of gastric ulcer in mice stomach under dissecting microscope revealed increase number and length of ulcer in mice administrated with alcohol. Groups administered with naproxen, X2, F57 also showed evidence of ulceration however less compared to groups administered with alcohol. Moreover number of ulcers where significantly less in X23 group, while X3 treated animal showed no evidence of ulcers or hemorrhage seen in stomachs after examined under dissecting microscope). Histopathological sections of stomach mice treated orally with 250mg /kg of naproxen,X2, F57 groups and X23 for 5 days show severe distractions of stomach mucosa, necrosis of intestinal villi with inflammatory cell infiltration in lamina properia and severe ulceration and necrosis of intestinal mucosa with congestion of blood vessels. The result of the X3 group was most prominent and revealed small intestine increase in number of goblet cell with increase amount of mucin seen in the lumen with mononuclear cell infiltration with lymphoid tissue that give good chance for increase immune tissue and resistant ulcer.

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