Antibiotic sensitivity in pseudomonas areuginosa in taiz, yemen-2013

Pseudomonas aeruginosa is an important opportunistic pathogen that infects immune compromised hosts and is characterized by its natural resistance to a variety of antimicrobial agents. The purpose of this study was the assessment of the some antimicrobial sensitive level among P. aeruginosa clinical isolates, furthermore to compare between the different antibiotics among the susceptible and sensitivity by isolates of P. aeruginosa also to detect the most potent drug on P. aeruginosa. A total of 65 clinical isolates of P. aeruginosa from the patient in different laboratories in Taiz city, as following Aljomhory hospital laboratories (50) isolates, alpharaby laboratories (15) isolates. Most of the isolates were from ear followed by urine. Uropathogenic P. aeruginosa infections were higher in females than males, ratio was found more among young and elderly debilitated patients. The result is Ciprofloxacin, amikacin, tobramycin were found more effective as monotherapy for treatment of infections in patients. The most studied case indicate the P. aeuroginosa was resistant to most β-lactam particularly resist 100% to ticarcillin. In vitro sensitivity pattern of 65 isolates of P. aeruginosa showed highest sensitivity to ciprofloxacin (75%) followed by amikacin (65%), tobramycin (62%), and were much more resistant to β -lactam and norfloxacin antibiotics. the result of study by using combination therapy that we have use the following combinations which in all combinations are indicate to synergistic action (Ciprofloxacin+gentamycin), (Ciprofloxacin+Amikacin), (Ciprofloxacin+Ceftriaxone). Finally all the results indicate that P. aeruginosa is the most common gram-negative bacterium responsible for the nosocomial as well as community acquired infections. And the excessive use of antibiotics has not only led to treat the P. aeruginosainfections but also the emergence of antibiotic resistance.