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Table of Contents: Volume 17; Issue 04; April 2025

Life Sciences

  1. Rohini Ojha and Dr. B.K. Mehta
    ABSTRACT:

    Butea monosperma belongs to family leguminoaceae. It is locally called as Palas, Dhak and Khakhra. A lot of scientific literature is also available in which extract of its bark was used as astringent in diarrhoea. Here, we report three new compounds from EtOAc: MeOH and MeOH fraction of ethanol extract. 20-hydroxy noneicosan-7-oate, 3-O--D- glucopyranosyl-urs-12-ene-27, 28-dioic acid and 22.23-dihydro-4-stigmastene-3--D-glucopyranoside were the identified by spectral (IR, 1HNMR spectra, mass spectrum) and chemical analysis. These are novel compounds and being reported first time by us

  2. Jitendra K Pal, Jinal H Naik, Roshni Shukla and Harshvadan Patel
    ABSTRACT:

    Metagenomic has proven to be a powerful tool for investigating microbial diversity and functional potential within complex environments. Its application has steadily expanded, particularly in exploring the rhizospheric soil microbiome. The rhizosphere—the narrow region of soil influenced by root exudates— notably contribute in plant growth-promoting rhizobacteria (PGPR), which play essential roles in enhancing plant growth. These beneficial bacteria contribute through various mechanisms such as nitrogen fixation, phosphate solubilization, and phytohormone production. Material and methods: Two soil sample from different rhizosphere were collected from Jeevkar Nagar (garden area) and Ishwar Farm (sorghum field) from two different location of Surat, India. Further Bacterial DNA was isolated, purified and quantified. After library preparation samples was sequenced using Sequencing with ion torrent s5 plus system and analysed using alpha diversity analysis method. Results: In our sample analysis three major group of bacterial community dominate the diversity of particular soil microflora respectively, Proteobacteria (76.89 %), Actinobacteria (12.8) and Firmicutes (2.36 %) with minor presence of other bacterial community. Microbial community taxonomic analysis shows 20, 21 phyla; 40,39 class; 55,52 order; 53,50 family; and 55,51 genus and species in sample 1 and sample2 respectively. Conclusions: This study highlights the effectiveness of metagenomics in uncovering the hidden diversity and functional capabilities of PGPRs in rhizospheric soils. The insights gained pave the way for the development of advanced microbial strategies to promote sustainable agriculture and enhance soil health.

  3. LOZO Roméo N’Guessan, BERTE Siaka, N’GUESSAN Koffi Richard and KOUAMELAN Essetchi Paul
    ABSTRACT:

    The Bandama river basin offers a highly diversified range of environments: lacustrine environments and lotic environments respectively upstream of Lake Kossou, downstream of Lake Taabo and between the two lakes. It is exposed to various types of anthropogenic pressure that can disrupt its ecological functioning. Conservation of its biodiversity in order to ensure effective and sustainable management of its resources requires a better understanding of one of the primary biological compartments of the food web, which is made up of micro-algae. The aim of this study is to determine the population and distribution of phytoplankton in the waters of the Bandama River. The physico-chemical parameters (pH, Temperature, Conductivity and Dissolved Oxygen) were measured in situ using a portable multiparameter HANNA model HI9828. Samples were taken using a plankton net with a mesh size of 20 µm. The various sampling campaigns took place each season throughout 2013. Out of a total of 170 phytoplankton taxa, the Chlorophyta phylum had the highest number of taxa with 75 species, or 44.11%. Next come the Euglenophyta (44 taxa or 25.88 %), the Heterokontophyta (36 taxa or 21.17 %), the Cyanoprokaryota (12 taxa or 7.05 %) and finally the Dinophyta (3 taxa or 1.76 %). The results of the Redundancy Analysis showed that Chlorophyta and Cyanoprokaryota have a preference for nutrient-rich environments. pH and temperature had a much greater influence on the distribution of Chlorophyta. This study assesses the influence of physico-chemical parameters on the population and distribution of phytoplankton in the waters of the Bandama river basin.

  4. Raj Karavadra, Kunal N. Odedra, Smit Sindhav and Jadeja, B. A.
    ABSTRACT:

    Seed germination and seedling establishment are critical phases in the life cycle of Trachyspermum ammi (Ajwain), a medicinally and economically important plant. While sowing depth and soil type are known to influence these stages, their combined effects on Ajwain remain understudied, particularly in diverse agroecosystems. This study investigated the impact of four sowing depths (0, 1, 2, and 3 cm) and four soil types (red, black, sandy, and alluvial) on germination indices and seedling growth parameters. The experiment was conducted in controlled conditions using plastic bags, with germination percentage (GP), mean germination time (MGT), germination speed (GS), and seedling morphological traits monitored over six weeks. Data were analyzed using non-parametric tests and multivariate techniques, including Principal Component Analysis (PCA). Results revealed that shallow sowing (0 cm) in alluvial soil yielded the highest GP (60%), GS (3.00), and GI (5.00), while deeper sowing (2–3 cm) significantly reduced germination performance, particularly in sandy soil. Seedling growth was optimal at 1 cm depth, with sandy and alluvial soils promoting superior stem diameter and leaf development. PCA highlighted a trade-off between germination vigor (PC1) and seedling establishment (PC2), with 0 cm favouring germination and 1–2 cm enhancing later growth. Soil type played a secondary but notable role, with alluvial soil exhibiting resilience across depths. These findings emphasize the importance of shallow to moderate sowing depths (0–1 cm) for Ajwain cultivation, especially in well-drained soils like alluvial or sandy types. Farmers can leverage these insights to improve crop establishment and uniformity. Limitations include the study’s-controlled environment and focus on early growth stages. Future research should explore field-scale trials, long-term yield effects, and interactions with abiotic stresses to refine agronomic practices for T. ammi and similar small-seeded medicinal plants. This study contributes to optimizing cultivation strategies while highlighting the need for further ecophysiological investigations.

  5. Ricardo Bemfica Steffen and Gerusa Pauli Kist Steffen
    ABSTRACT:

    Global agriculture is rapidly adopting bioinputs for the sustainable management of crops. The use of symbiotic fungi and bacteria marks a significant technological advance towards cleaner, more efficient, and regenerative farming practices. Stimulating the activity of beneficial microorganisms in the soil is crucial for achieving high productivity while minimizing environmental impact. In this study, microbial agents commonly used in global agriculture were evaluated for their response to the biostimulant product Penergetic “p”. In vitro tests were conducted using both liquid and semi-solid fermentation of biological agents, with and without the biostimulant in the culture medium. Microbial growth and development were assessed based on growth diameter and spore count. The results showed that Penergetic “p” effectively stimulated the growth and development of all evaluated microbial agents, with average increases of over 35% for fungi and 130% for bacteria. This biostimulant has proven to be an efficient tool for enhancing the activity of microbial agents in agriculture.

  6. Swamy, K.R.M.
    ABSTRACT:

    Parsley belongs to the family Apiaceae (Umbelliferae), genus Petroselinum, and species Petroselinum crispum. Other scientific names are: P. hortense Hoffm., P. sativum Hoff., Carum petroselinum (L.) Benth. and Hook. F. Parsley has the following common names: English–parsley, Chinese–heung choi, Danish–persille, Dutch–peterselie, French–persil, German–petersilie, petersil, peterwurz (root), Greek-maintanos, makedonisi, petroselino, Hindi–ajmood, Italian–prezzemolo, Polish–pietruszka zwyczajna, Portuguese–salsa, Russian–petrushka, Spanish–perejil, Swedish–persilja. Parsley is mostly cultivated as an annual culinary herb and is widely grown in Europe and Western Asia. Parsley is to the Western world what cilantro (sometimes called Chinese parsley or coriander) is to the Eastern world. Most parts of the plant are used – the leaves, the above-ground herb and the seeds. The essential or volatile oils can be obtained through distillation. The volatile oil obtained from the above-ground herb has the aroma of the fresh herb and is marketed as herb oil. The volatile oil obtained from the seed has a unique distinctive flavour and is marketed as seed oil. It is interesting to note that the name ‘parsley’ originates from the name Petroselinum ascribed by Dioscorides. Later on, in the Middle Ages it became petrocilium and later expressed in the English language as petersylinge, persele, persley and finally parsley as it is known today. The name petroselinum is derived from the Greek word petros which means stone, referring to the plant’s habit of growing in rocky places. Selinon was the Greek word for parsley in ancient history. Parsley has been known in the Mediterranean region for about 2000 years, where it was cultivated as a medicinal plant. Parsley, a vital culinary and medicinal herb from the Apiaceae family, boasts significant nutritional and therapeutic benefits. Originated from the Mediterranean region, this wonderful herb is a coffer of many phenolic compounds and flavonoids such as apigenin and apiin, essential oils primarily consisting of myristicin and apiol, as well as coumarins. Genetic resources of parsley are considerably represented in ex situ collections worldwide, and the passport data can be retrieved from several database sources. Genetic diversity of this crop needs to be conserved with immediate attention to avoid genetic erosion. Decades of breeding efforts in parsley including selection and interspecific and intervarietal hybridization have led to the development of numerous high-yielding cultivars with biotic stress tolerance and enrichment in essential oil. Despite these achievements, the production potential of parsley of different categories remains significantly low. The growing demand for high and sustainable parsley production drives the scientific communities to increase breeding efficiency, ensuring a continuous supply of improved cultivars. Integration of conventional breeding strategies with cutting-edge molecular breeding tools deploying genomic resources can pave the way for cultivar development in shortest possible time. Pressing need has been felt to enrich the genomic resources vis a vis genetic resources toward development of high-yielding parsley cultivars with key adaptive traits against the climatic vagaries along with nutritional benefit and therapeutic importance. In this review article on Origin, Taxonomy, Botanical Description, Genetic Diversity, Breeding and Cultivation of Parsley are discussed.

  7. Swamy, K.R.M.
    ABSTRACT:

    Chives belongs to the family Alliaceae, genus Allium, and species Allium schoenoprasum. English chive derives from Latin cepa onion via Middle English cyve or cheve, a loan from Old French cive. Note that the singular chive is used for the plant, whereas the spice is usually referred to as plural form chives. The botanical species name schoeno¬prasum means essentially rush-like leek: Greek schoinos rush (a kind of grass, genus Juncus) and prason leek. The reference is, obviously, to the leaves’ shape. Cf. also the Modern Greek name praso . In quite many lan¬guages, chives are denoted as a grassy variant of their larger relatives, leek, onion and garlic. Examples from Scandi¬navia are Swedish gräs¬lök, Nor-wegian gras¬løk, Estonian muru¬lauk and Finnish ruoho¬sipuli grass-onion; similar are Catalan all junci-forme rush-shaped garlic, Arabic waraq basal onion-leaf and Hebrew irit basal asphodel-onion, where asphodel refers to a Medi¬terranean type of lily with hollow leaves (e. g., Asphodelus fistulosus) also known as onionweed. Other languages use geo¬graphical epithets like Bulgarian luk sibirski Siberian onion or Turkish frenk soğanı Frankish onion. In the Romance language, the names of chives are often diminutives formed from onion meaning little onion or (if you like that) onionlet: French civette, Spanish cebollana, Italian erba cipollina and Portuguese cebolinho. There are two types of chives: 1) Common chives (Allium schoenoprasum) with grass like foliage that is round and hollow and globe-shaped mauve flowers. And 2) Garlic or Chinese chives (Allium tuberosum) with flatter leaves that have a mild garlic flavour and white, star shaped flowers. Both types grow well in the ground or in pots and can cope with extended periods indoors on a sunny window sill. In the veggie patch or in the garden, chives make a great decorative border plant. Chromosome number 2n = 16, 24, 32. There were no written records of domesticated chives from the Mediterranean region until the 16th century in Europe, whereas in East Asia chives have been domesticated since ancient times. At present chives are cultivated as vegetables or seasoning herbs all around the world, especially in the Northern Hemisphere. Because chives are very adaptable, tolerant of cold and hot temperatures, and grow rapidly, they can be cultivated and harvested many times throughout the year. They are also easy to propagate, either from seeds or from division of clumps all year round. Chives are grown mainly for their long, cylindrical leaves, used for culinary purposes. Their flowers can also be used for salad dressings and sometimes for decorative purposes. Chive is the smallest species of Allium genus and family Alliaceae, which includes other crops such as shallot, onion, garlic, leek and bunching onion. Chive is a nutrients rich food, meaning that while it is low in calorie, it is high in beneficial nutrients like minerals, vitamins and antioxidants too. It is an excellent substitute of salt and a perfect aid for those who are on a low-fat and salt-restricted diet. Chive is mainly used as garnish, and its fresh chopped leaves are stir-fried and used as flavoring in dumplings, soups, stews, pasta, salads. Chive is a monocot, small perennial herb growing in clumps. Plants can be grown from seed or divisions of 2 to 3 bulbs. In this review article on Origin, Taxonomy, Botanical Description, Genetic Diversity, Breeding and Cultivation of Chives are discussed.

  8. Dr. Renu Kumari
    ABSTRACT:

    A series of 37 compounds of Purine-Based Hydroxamic Acid Derivatives were taken from the literature with inhibitory activity pIC50. In the present study, we try to model some drug molecules acting as HDAC1 inhibitors with antitumor activities. For QSAR studies, out of 30 compounds, compounds (75%) were selected for the training set by random selection, using Statistica Data miner software, for the generation of the model, and the remaining seven compounds (25%) were used for the test set. The multiple linear regression method was applied to select the descriptors .The two parametric model were found to be the best which gave the variance of more than 90%( R2=0.902). Our results have indicates that the negative values of the descriptors ATSC6i and C-008 refer to a decrease in centered broto Moreau autocorrelation of lag 6 weighted by ionization potential, hydrophobicity and molecular refractivity will enhance the activity of the molecule. We also predicted some new compounds, as reported in Table 6, where each compound has a higher activity value than any compound in the existing series (Table 1).

Physical Sciences and Engineering

  1. OSSOKO Jean Paul Latran, OKANDZA Yves, MIAKAYIZILA Snelle Baonda, ANSALLA GAMPIO Dick Mirsen , DZONDO Gadet Michel and MVOULA TSIERI Michel Didace
    ABSTRACT:

    This study investigated the nutritional value of Irvingiaexcelsa (Payo) kernels from Pokola, Republic of Congo. We conducted physicochemical analyses according to the AOAC standard. Analyses of these kernels revealed that they have a low water content (2.89±1.15%), which explains their long shelf life. Fiber, ash, and protein contents were also low (1.22±0.44%; 3.90±0.14%; and 7.28±1.45%, respectively). However, the lipid content was high (43.97±2.47%), as was the carbohydrate content (44.85%), and the calculated energy value was 604 kcal/100g. Some chemical indices of the extracted oil were determined. The acid value is 2.95±0.26 mg KOH/g; the peroxide value is 1.92±0.12 meq O2/kg; and the saponification value is 151±1.26 mg KOH/g. Irvingiaexcelsa kernels have appreciable nutritional quality; their oil is unaltered and is of interest in the cosmetics industry.

  2. Neha Snehi
    ABSTRACT:

    Dyslexia is a learning difficulty that mainly affects reading, writing, and spelling. However, it can also lead to emotional and mental challenges for those who have it. People with dyslexia often face difficulties in understanding written words, which can make tasks like reading books or writing essays much harder. These challenges are not a result of a lack of intelligence, but rather how the brain processes language. This article looks at the emotional problems that people with dyslexia often face, such as feeling frustrated, anxious, or having low self-confidence. For example, struggling with schoolwork can make students feel embarrassed or less capable than their peers. It also examines how these emotions can impact their school performance, relationships with others, and overall well-being. Feelings of frustration may cause them to avoid school activities or social situations, leading to isolation. In some cases, it can even affect their motivation to learn or participate in certain activities. The article reviews existing research to explain why people with dyslexia may struggle emotionally. It discusses how challenges in learning can lower self-esteem, making it harder for individuals to stay positive or confident in their abilities. The article also offers ideas for support, such as tailored teaching strategies or therapies to help individuals cope with both their learning difficulties and emotional struggles. These strategies aim to help individuals manage their emotions, build self-confidence, and improve their academic performance. Additionally, family support, patience, and understanding from teachers and peers can make a big difference in the lives of those with dyslexia. By focusing on both the emotional and educational needs of individuals, it is possible to improve their overall quality of life.

  3. Victor Rogelio Tirado Picado
    ABSTRACT:

    The main objective of this research was the analysis of basic infiltration implementing the modified Porchet method at three points of different soil textures, to address this it was required to establish the pertinent theory, then the method was developed and Modified Porchet was proposed, and finally, a new infiltration test method of easy implementation was established. First of all, in accordance with the established hypothesis, it was possible to demonstrate that the Porchet method for performing soil infiltration tests accepted modifications, establishing a new Porchet method modified by TIBLA. With the Porchet method modified by TIBLA, it was possible to quantify basic infiltration, resulting in a loamy texture for the first point, a loamy texture for the second point, and a clayey loam texture for the third point.

  4. Nweke, I. A., Ijeh A. C., Okafor, J. M., Okenmuo, F. C., Ernest, C. I., Uko, I., Anene, C. K.,3Obidiebube, E. A., Nwankwo, J. E., and Ogalanya, F. C.
    ABSTRACT:

    An experiment was conducted at the University of Nigeria Nsukka Experimental Farm to determine the water use by maize (Zea mays L.) from its early period of growth to maturity at three (3), nitrogen levels of 100kgN/ha, 130kgN/ha and 160kgN/ha. A modified field water balance equation was employed to approximate the water use. This was compared with the Blaney and Criddle formula. Result findings showed that with the modified field water balance equation 365.63mm was the water use. The water use by maize crop at different N levels were relatively the same. With the Blaney and Criddle formula the calculated consumptive use was 307.34mm, thus approximately 19% difference was noted in the two methods. With the result one can estimate the amount of water need and farm water application efficiency for maximum maize production in southeastern soils of Nigeria.

Health Sciences

  1. Prerna
    ABSTRACT:

    This exploratory study examines the current policies and identifies gaps in programs for persons with disabilities (PWDs) in India. While India has made progress in implementing the Rights of Persons with Disabilities Act, 2016 and launching various programs and initiatives, there is still a long way to go to ensure full inclusion and access for PWDs in all aspects of society. The study investigates the policies and programs implemented by different ministries, including the Ministry of Social Justice and Empowerment, Ministry of Health and Family Welfare, Ministry of Education, Ministry of Rural Development, and Ministry of Railways. The study highlights the fragmented nature of policies and programs, lacking comprehensive coordination and resulting in duplication of efforts and limited coverage. Implementation challenges, such as inadequate funding, lack of awareness, and limited accountability mechanisms, hamper the impact of these initiatives. The study also identifies the need for policies and programs to address the diversity and intersectionality of disabilities, taking into account factors such as gender, age, location, and type of disability. Furthermore, the study emphasizes the importance of capacity-building for PWDs and their organizations to participate in decision-making processes and advocate for their rights. It highlights the need to involve PWDs in policymaking and program design to ensure their perspectives and needs are adequately represented. The lack of reliable data on PWDs in India is another significant challenge, hindering evidence-based policymaking and program design. The study calls for improved data collection and management to better understand the challenges faced by PWDs and design effective interventions. In conclusion, while progress has been made, there are still significant gaps in policies and programs for PWDs in India. The study suggests the importance of creating an accessible environment, promoting equal engagement in mainstream society, and celebrating human diversity to empower PWDs. It also calls for improved coordination, increased funding, and greater inclusion of PWDs in decision-making processes to address the existing gaps and ensure equal access and opportunities for all.

  2. Shruti Mahajan, Dr. Khushwant Singh Rathore and Dr. Raghvendra Choubey
    ABSTRACT:

    Introduction: Low back pain is a common problem in rural India as well. The lifestyle, working conditions, and health practices in these areas differ with those in urban environments. Research aimed at addressing low back pain in rural settings can help create targeted interventions that are both feasible and effective within the rural healthcare framework. Pilates, a holistic program that addresses both mental and physical conditioning, is frequently recommended by doctors and physiotherapists for managing chronic low back pain. Objective: To assess the effect of pilates exercises on pain and functional disability in patients with chronic non specific low back pain in Bundelkhand region. Design: Quasi experimental study design. Participants: A total of 30 patients with chronic non-specific low back pain who met the inclusion and exclusion criteria and provided consent to participate were included in this study. Intervention: Participants attended 24 mat Pilates sessions, with 4 sessions per week for a duration of 6 weeks. Main Outcome Measures: The Visual Analog Scale (VAS) was utilized to measure pain intensity, while the Oswestry Low Back Pain Disability Questionnaire (OSWDQ) was employed to evaluate functional disability. Assessments were carried out both prior to the initiation of treatment and following its conclusion. Result: The results indicated significant improvements in functional activity and a reduction in pain following the intervention (p < 0.05). Conclusion: The study demonstrated that Pilates significantly enhances the management of chronic non-specific low back pain in patients from the Bundelkhand region. The intervention led to notable improvements in functional activity and a reduction in pain. These findings suggest that incorporating Pilates into treatment protocols can be an effective strategy for alleviating pain and improving functionality in this patient population.

  3. Ahmed Alharthi and Dr. Sanaa Alsulami
    ABSTRACT:

    Background: Telehealth is expanding in Saudi Arabia, driven by Vision 2030, but faces challenges like technology gaps, providers training issues, and policy limitations. Addressing these barriers is the key to successful implementation and improved healthcare access. Objectives: The aim of this systematic review is to examine the latest literature on the challenges faced by healthcare providers in Saudi Arabia during the implementation of telehealth services. The utilization of telehealth as an effective means to provide quality services is steadily rising across different tiers of the health system. However, advancing telehealth utilization relies on the current healthcare systems’ infrastructure, policies, cultural factors, and utilization requirements can influence the utilization of telehealth within Saudi Arabia’s healthcare system. Methods: this systemic review conducted in three electronic databases—CINAHL (cumulative Index to Nursing and Allied Health Literature), Medline, and PubMed—targeting studies published between January 2019 to December 2024. The search used keywords derived from the PICO (Population, Intervention, Comparison, and Outcome) framework, focusing on telehealth, healthcare providers, and challenges specific to Saudi Arabia. The review followed PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, incorporating strict inclusion and exclusion criteria. Studies were included if they were: original research articles, published in English, peer-reviewed with full text available, conducted in Saudi Arabia, published between 2019 and 2024, and focused on challenges faced by healthcare providers in telehealth implementation. 16 studies achieved these norms. The quality of studies was assessed using the CASP (Critical Appraisal Skills Programme) and Quadstools, and data were systematically extracted to identify key themes and barriers. Results: The findings revealed that several challenges to telehealth implementation. Technological issues, such as poor internet connectivity and poor infrastructure. Training gaps and limited provider knowledge also slowing telehealth adoption. Cultural resistance, privacy concerns, and diagnostic limitations further complicated its effective use. Additionally, Policy Issues and financial problems. Conclusion: Telehealth has the potential to transform healthcare delivery in Saudi Arabia. However, addressing the barriers is important to realizing its full benefits. Investments in infrastructure, providing training programs, and clear regulatory frameworks are essential. These measures will align telehealth with Saudi Vision 2030, ensuring equitable and efficient healthcare access across the Kingdom.

  4. Shreya Agarwal, Dr. Koustuv Chowdhury, Dr. Lopamudra (Dhar) Chowdhury and Dr. Rohan Mandal
    ABSTRACT:

    Cornelia de Lange syndrome (CdLS), a rare congenital disorder, is estimated to occur in approximately 1 in 10,000 to 1 in 30,000 live births, and there's no specific data on its incidence in India, but it's believed to be a global condition with no racial predilections. As mild cases of CdLS often are not reported, the incidence and prevalence are probably underestimated. Presently, the estimated incidence in the United States has been reported between 1 per 10000 to 1 per 50000 newborns. The disorder affects males and females equally due to a dominant genetic pattern(1). Epilepsy manifested between age 6 months and 16 years. The majority of patients (64.3%) presented with seizures and interictal EEGs mainly revealed focal epileptic paroxysms involving temporal and parietal areas. The majority of the seizures were controlled by Sodium Valproate monotherapy. Otherwise monotherapy with topiramate, levetiracetam, carbamazepine and oxcarbazepine is also effective in controlling seizures. CdLS is a developmental disorder that affects many parts of the body. The features of this disorder vary widely among affected individuals and range from relatively mild to severe. There are various genetic variations that contribute to CdLS. • NIPBL gene (Chromosome 5p13.2) – is the most common cause (60-70%) • SMC1A gene (X chromosome, Xp11.22) – accounts for 5-10% of cases. • SMC3 gene (Chromosome 10q25) – A rarer autosomal dominant cause. • RAD21 gene (Chromosome 8q24.11) – a milder form of CdLS. • BRD4 gene (Chromosome 19p13.12) – rare contributor to CdLS. In this particular case we have discussed the presentation, management, investigation, finding, diagnosis of gene mutation BRD4 related CdLS in a girl 5years old.

  5. Anurag Aher and Dr Komal Gunjal
    ABSTRACT:

    Background: Spinal cord injuries (SCI) often result in significant motor impairments, limiting patients ability to perform daily activities independently. Traditional rehabilitation approaches have shown effectiveness but often lack engagement and specificity in targeting motor control deficits. Emerging technologies, such as virtual reality (VR), offer promising avenues for enhancing motor rehabilitation in SCI patients. Objective: The aim of this study was to assess the impact of a virtual reality-based exercise program on motor control in SCI patients, focusing on improvements in upper extremity function, trunk control, balance, and spasticity. Methods: This pre-post experimental study was conducted at the Neuro Physiotherapy Department of Dr. APJ Abdul Kalam College of Physiotherapy, Pravara Institute of Medical Sciences, Loni, Ahmednagar. A total of 15 participants with incomplete SCI, aged 20-65 years, were selected using convenient sampling. Participants underwent VR training for 30 minutes daily along with 3 hours of daily therapeutic exercises for four weeks. Pre- and post-intervention assessments were conducted using the Voluntary Motor Control Grading Scale (VMCGS), Fugl-Meyer Assessment Scale (FMA), Modified Functional Reach Test (mFRT), and Modified Ashworth Scale (MAS). Results: The results demonstrated significant improvements in all outcome measures post-intervention. The mean score for VMCGS increased from 2.066 ± 0.7988 to 4.066 ± 0.7988 (p < 0.0001), indicating enhanced upper extremity motor control. The mean score for FMA improved from 14.733 ± 3.01 to 23.333 ± 3.754 (p < 0.0001), reflecting better motor function. The mean score for mFRT increased from 17.133 ± 1.187 to 23.266 ± 1.751 (p < 0.0001), indicating significant gains in balance and trunk stability. The mean score for MAS decreased from 2.933 ± 0.7988 to 1.933 ± 0.7988 (p = 0.0019), showing a reduction in spasticity. Conclusion: This study concludes that VR-based exercise programs can significantly enhance motor control, balance, and spasticity in SCI patients. The interactive and engaging nature of VR therapy provides an effective and motivating approach to rehabilitation, complementing conventional techniques. These findings suggest that integrating VR technology into clinical practice can improve the quality of care and outcomes for SCI patients.

  6. Ambaga, M., Tumen-Ulzii, A. and Buyantushig, T.
    ABSTRACT:

    The Ambaga Closed 9-Stepped Cycle of Proton Conductance is one of the most fundamental systems that emerged during biological evolution, and its formation was driven by the force of electrophile - nucleophile interactions. This is supported by the following scientific foundations: Origin of Life and the Role of Electrophile - Nucleophile Forces After the Big Bang, protons (H⁺) and electrons (e⁻) became the essential energy carriers of the universe. These charged particles established electrophilic (electron-accepting) and nucleophilic (electron-donating) forces as the fundamental chemical drivers in biological environments. 2. Release of Hydrogen Atoms from Food Molecules Initiates Proton Flow. During the first step of catabolism, hydrogen atoms are cleaved from food molecules (glucose, lipids, amino acids), generating electrons (e⁻) and protons (H⁺). This process is governed by electrophile–nucleophile reactions, where electron-accepting cofactors (e.g., NAD⁺, FAD) act as electrophiles, and enzyme functional groups act as nucleophiles. 3. Each Step in the Proton Conductance Cycle Involves Electrophile - Nucleophile Interactions

  7. Abdul Rahman, Murad Hussain, Nazia Khan, Mohammed Aamir and Albin Matthew
    ABSTRACT:

    India has taken a bold and ambitious step in committing to end tuberculosis (TB) by 2025, ahead of the global target of 2030. This commentary explores the strategies adopted for scaling up quality assurance (QA) in TB diagnostics, which forms the backbone of accurate, timely, and efficient case detection and management. It discusses political leadership, technological integration, private sector engagement, surveillance indicators, and economic support mechanisms, and analyzes how these strategies have improved the TB diagnostic landscape in India. It concludes with a reflection on key challenges and future directions required to sustain momentum in India's TB elimination efforts.

  8. Dr. Niharika Khullar
    ABSTRACT:

    Children with trisomy-21 have predisposition to develop Myeloid Leukemia of Down syndrome.(ML-DS). ML-DS is associated with TAM (Transient Abnormal Myelopoiesis) a haematological disorder of infancy, thought to originate in utero, as an identical mutation in GATA1 gene Most TAM cases will undergo spontaneous resolution without treatment, they don’t require chemotherapy unless there is life threatening complication. We present a case of 16 month old female presented with complaints of fever &decreased activity, down's facies. On Complete blood count Hb-3.7, total count-19400, differential leukocyte count –blast-50%, & neutrophil 21%, lymphocyte-25%, eosinophil 1%, monocyte-3%, basophil-0%. Immunophenotyping of pheripheral blood by flow cytometry showed CD34, CD45, CD33, CD13, CD117, aberrant CD7, CD36, CD56, Cyto CD61-positive. s/o amegakaryocytic leukemia M7.Karyotyping confirmed DS. Patient completed 4 cycle of chemotherapy out of 4 cycles. Subject Area: paediatrics

  9. WEINTA Massama and Dr. Hergie Alexis SEGUEDEME
    ABSTRACT:

    The journey from innocence to experience is a fundamental rite of passage that countless literary protagonists undergo. In the novels Silas Marner Oranges Are Not the Only Fruit, the central characters Silas Marner and Jeanette embark on transformative arcs that strip them of their innocence and naivety. While the specific circumstances differ, both narratives explore the underlying societal, religious, and interpersonal factors that precipitate this loss of childlike purity. Eliot's Silas Marner depicts the title character's descent from a respected member of a Puritan community into solitude and misanthropy after being falsely accused of theft. Winterson's semi-autobiographical novel chronicles a young girl's struggle to reconcile her burgeoning sexuality with the rigid doctrine of the Pentecostal church in which she was raised. Though set in vastly different eras and contexts, these works unveil the myriad forces that can disrupt one's innocence.

  10. Ojas Vijayanand Potdar
    ABSTRACT:

    Objective: To evaluate the clinical outcomes of over-dilatation versus under-dilatation during PCNL in a cohort of 200 patients, analyzing its impact on operative time, stone-free rates, complications, and renal function. Methods: A prospective, randomized study was conducted on 200 patients undergoing PCNL for renal calculi. Patients were divided into two groups: Group A (over-dilatation, n=100) and Group B (under-dilatation, n=100). Primary outcomes included stone clearance rates, intraoperative and postoperative complications, and renal function preservation. Secondary outcomes included operative time and hospital stay duration. Randomization was performed using a computer-generated sequence, and all procedures were standardized with experienced surgeons. Statistical analyses included chi-square tests for categorical data and t-tests for continuous variables. Results: Over-dilatation was associated with a higher stone-free rate (85% vs. 72%, p<0.05) but increased risk of bleeding requiring transfusion (10% vs. 4%, p<0.05). Under-dilatation resulted in longer operative times (78 min vs. 64 min, p<0.05) and a higher rate of residual fragments requiring auxiliary procedures (22% vs. 12%, p<0.05). No significant difference in long-term renal function deterioration was observed between groups. Conclusion: Over-dilatation in PCNL provides superior stone clearance but comes at the cost of increased bleeding risk. Under-dilatation prolongs operative time and increases the likelihood of secondary procedures. A balanced approach to tract dilation is recommended to optimize outcomes.

  11. Dr. Tamasi Choudhury, Dr. Lopamudra (Dhar) Chowdhury, Dr. Koustuv Chowdhury and Mr. Abhik Saha
    ABSTRACT:

    Introduction: Toxic epidermal necrolysis (TEN) is a severe cutaneous adverse drug reaction characterized by widespread erythema, necrosis, exfoliation and bullous formation of epidermis and mucous membranes which may cause sepsis and death.Medications are the most common causative factor for TEN. Case Details: A 31 years old male with past history of bipolar disorder was on Lithium and Sodium valproate. Due to elevation of liver enzymes discontinuation of lithium and valproate done. After 1 year patient developed right-sided facial pain with hyperalgesia,attended to Neuromedicine OPD and diagnosed as a case of Trigeminal neuralgia and advised to take Carbamazepine. After 2 weeks the patient developed bilateral conjunctivitis, generalized erythematous rash, exfoliation, mucosal surface involvement of mouth and genitalia with subsequent ulceration. The patient was diagnosed as a case of toxic epidermal necrolysis,liver enzymes were found elevated for which Carbamazepine was discontinued immediately, and treated conservatively. Adverse drug reaction was reported to ADR monitoring center. Causality assessment was found probable by WHO (UMC) scale and Naranjo scale. Conclusion: Toxic Epidermal Necrolysis is an emergency condition having high rate of morbidity and mortality. Early diagnosis and intervention with timely withdrawal of the offending drug can save the life of patients.

  12. Dr. Vishal Lodha, Dr. Dhaval Rasal, Dr. Shashank Patil, Dr. Sanjay P Dhangar, Dr. Sonu Kumar Plash and Dr. Ketan Vartak
    ABSTRACT:

    Background: Lower urinary tract symptoms (LUTS) significantly impact women's quality of life. This study evaluates the efficacy and safety of a combination of tamsulosin and mirabegron in treating LUTS in women. Methods: A prospective, observational study was conducted involving 50 female patients treated with tamsulosin (0.4 mg) and mirabegron (50 mg) daily for 12 weeks. Primary outcomes included reductions in International Prostate Symptom Score (IPSS) and Overactive Bladder Symptom Score (OABSS). Secondary outcomes assessed patient satisfaction and adverse effects. Results: The combination therapy resulted in a significant reduction in IPSS (mean reduction of 10.2, p < 0.001) and OABSS (mean reduction of 5.1, p < 0.001). Uroflowmetry parameters also improved, with increased maximum flow rate (Qmax) and reduced post-void residual (PVR) volume. Mild adverse effects occurred in 26% of patients. Conclusion: Tamsulosin and mirabegron combination therapy is effective and well-tolerated for managing female LUTS, warranting further investigation in larger studies.

  13. Dr. Loyce Japhet Bagenda
    ABSTRACT:

    Triple-negative invasive ductal carcinoma (TNIDC) is a subtype of breast cancer that lacks expression of estrogen receptors (ER), progesterone receptors (PR), and human epidermal growth factor receptor 2 (HER2). This aggressive form of cancer accounts for approximately 10-20% of all breast cancers and is associated with a poor prognosis due to its high recurrence rate and limited treatment options. The present case report highlights a clinical presentation of a 46-year-old female diagnosed with TNIDC of the breast. She presented with a palpable mass in her right breast, and diagnostic imaging and biopsy confirmed the presence of invasive ductal carcinoma with triple-negative characteristics. The case plan of management was neoadjuvant chemotherapy. Pathologic examination confirmed the tumor's triple-negative status. The report emphasizes the importance of early diagnosis, genetic testing, and personalized therapeutic strategies, as well as the challenges in treating TNIDC due to its aggressive nature and resistance to hormonal therapies. This case underscores the need for continuous research into novel therapeutic agents, including immunotherapy and targeted treatments, to improve outcomes for patients with triple-negative breast cancer. Further investigation into biomarkers and potential targeted therapies could pave the way for more effective treatment regimens for this challenging disease.

  14. Jéssica Helena Franco Dorigatti, Symone Benedita Moreira de Macedo Bauman; Michele Akemi Nishioka, Fabiele Chieregato; Stephani de Almeida; Thaís Rodrigues, José Ricardo de Souza and Patricia Brassolatti
    ABSTRACT:

    The search for non-surgical treatments to treat localized fat and sagging skin has been growing in recent years. Currently, there is a significant search for facial harmonization, with improved contour and tissue rejuvenation. Due to its physical and biological characteristics, endolaser has been investigated for this type of therapeutic approach, but there is no consensus on the best parameters to use, including the wavelength. Therefore, the aim of this study was to evaluate a treatment protocol using the association of two wavelengths emitted simultaneously to improve facial contour and rejuvenation. For this purpose, a 61-year-old patient with an ageing appearance and moderate to severe sagging skin was selected. Photographs were taken to compare before and after, as well as a cutometer assessment of the sagging degree. The results showed an improved appearance of the skin tissue with a significant improvement in skin elasticity and viscoelasticity. As a result, we can conclude that endolaser treatment using two wavelengths simultaneously can reverse the age-caused damage, mainly by improving the tissue matrix and sagging skin.

Social Sciences and Humanities

  1. Pradeep Kumar Maurya and Dr. Sameer Tiwari
    ABSTRACT:

    Financial inclusion is a critical component of economic development, as it enables individuals and businesses to access financial services, manage risk, and invest in their future. This paper analyzes the current state of financial inclusion in Uttar Pradesh, India's most populous state, and identifies the key drivers and barriers to financial inclusion.

  2. Utkarsha Pawar, Dr. Rashmi Rangaswamy and Dr. Neha Wadhwa
    ABSTRACT:

    Background: Young adults face high levels of loneliness and difficulties in forming strong romantic relationships. Existing literature suggests a relationship between attachment styles, emotional intelligence (EI), and relationship quality. However, the moderating role of EI in these associations remains unexplored. Objective(s): This study aimed to examine whether emotional intelligence moderates the relationship between attachment styles and the quality of romantic relationships in young adults. Methods: A total of 310 participants aged 18–26 completed the Relationship Scale Questionnaire (RSQ), Schutte Self-Report Emotional Intelligence Test (SSEIT), and Investment Model Scale (IMS). Statistical analyses assessed direct relationships and moderation effects. Results: No significant relationships were found between attachment styles and emotional intelligence or between attachment styles and relationship quality. However, emotional intelligence significantly moderated the relationship between anxious attachment and relationship quality, but not for other attachment styles. Conclusions: Findings highlight the selective impact of emotional intelligence on anxious attachment, suggesting targeted interventions may improve relationship outcomes for individuals with this attachment style.

  3. Beatrice N. Manyasi
    ABSTRACT:

    The study investigated the nature of classroom activities used by learners to develop speaking skills and facilitate the acquisition of values in English language classrooms in secondary schools in Kenya. The research was guided by two central questions: What activities do learners engage in to enhance their speaking abilities? And how do these activities contribute to the development of values among learners? A qualitative case study design was employed to gain in-depth insights into classroom practices. The target population consisted of secondary school learners and English language teachers, with a purposive sample drawn from selected schools. Data were collected through classroom observations, focus group discussions with learners, and document analysis of instructional materials and learners’ written work for presentation in class. Findings revealed that learners actively participated in a variety of speaking-based activities, including role plays, group discussions, debates, storytelling, and oral presentations. These tasks not only supported the development of oral communication skills but also fostered the internalization of values such as respect, honesty, cooperation, and empathy. The activities created interactive environments where learners practiced both language use and social behaviors in meaningful contexts. The study concludes that classroom activities that are well-structured, learner-centered, and value-oriented serve a dual purpose in language education. They support the mastery of speaking skills while also contributing to the moral development of learners. The study recommends that language instruction should integrate value-based content through active speaking tasks, and that teacher training programs should equip educators with strategies to foster both communicative and ethical competence among learners.

  4. Dr. Jyoti Kumari
    ABSTRACT:

    Population structure tells about the population structure of an area. Population structure is very important in many months. The progress of any area can be understood through its population structure. The study of population structure provides the basis to analyse the social and economic structure of the population and the intensity in population structure is the main characteristic of any urban centre. The ward level studies have been conducted on the basis of some maps such as age, gender proportion, religion, literacy, population of scheduled caste and scheduled tribe in Ranchi Metropolitan. This type of study proves to be very helpful in majoritarian planning, development oriented plans and determination of population policy. Gender ratio in Ranchi city has decreased in 2011 as compared to 2001.The areas with highest gender ratio here are Kokar, Lalpur, Sainik Compound, Morabadi etc. High literacy is found in Ranchi city. Literacy is higher in the inner wards of the city as compared to the outer wards. The reason for which is the concentration of government employees of the city in these areas. The reason for low literacy in the outer parts of the city is the higher tribal population and activities there. Business structure is also very important in population structure. Working and non-working labourers indicate the prosperity and development of an area.Similarly, religious structure of population also has the capacity to influence the economic, social, political and judicial behaviour of the society. People of many religions and communities also live in Ranchi city.Due to their social and religious diversity, there is a difference in the productive behaviour of different classes. Business structure is also very important in population structure.

  5. Mr. Nagendra Kumar Mahto and Manrakhan Mahto
    ABSTRACT:

    This article focuses on the problem of wastage and stagnation in secondary education in Jharkhand, which is a major obstacle to the social and economic development of the state. The article examines the causes, effects, and possible solutions to this problem, analyzing data from 2000 to 2020. The article found that poverty, social discrimination, lack of quality education, and child marriage are the major causes of this problem. Additionally, wastage and stagnation lead to a shortage of skilled workers, unemployment, poverty, and social inequality. The article also suggests some strategies to address this problem, such as increasing investment in education, improving the quality of teachers, and conducting awareness campaigns.

  6. Alejandro Alviter-Aguilar, Pedro Arturo Martínez-Hernández, Enrique Cortés-Díaz, Alejandro Rodríguez-Ortega, José Luis Zaragoza-Ramírez y Elba Ronquillo-De Jesús
    ABSTRACT:

    Parthenium hysterophorus es una arvense importante por los daños que causa en agricultura, producción animal, salud pública y ecología en diversas regiones del mundo. Las características botánicas y fisiológicas de la arvense le proporcionan capacidad para su expansión. Esta capacidad está determinada por la robustez de la planta cuando alcanza la madurez fisiológica y logra el potencial en producción de biomasa, flores y semillas. Está presente en praderas de alfalfa en el Valle del Mezquital, Hidalgo, México, causando daño a la producción forrajera al acortar la vida útil de la pradera al posicionarse como planta única. El objetivo fue evaluar el comportamiento fenológico de P. hysterophorus por efecto de ambiente de crecimiento y altura de planta. Los dos ambientes de crecimiento fueron secano e irrigación, Se seleccionaron al azar tres tipos de plantas: pequeñas, medianas y grandes. En cada planta se evaluó: diámetro de copa; longitud de raíz; altura de planta; diámetro de tallo, raíz y flor; número de ramas, hojas, inflorescencias, flores y semillas; peso total de planta húmeda y seca. Las plantas en ambiente de irrigación presentaron diferencias estadísticas (p<0.05) para producción de flores con 2,730.3±483.2 que se expresan en 13,651.6±2,416.1 semillas/planta, comparadas con plantas de secano con 1,350.8±483.2 flores y 6754.3±2416.1 semillas. Las plantas con alturas mayores que 100 cm tuvieron en promedio 4,054±591.8 flores, que se expresan en 20,270±2959.1 semillas, rendimiento estadísticamente diferente (p<0.05) de las pequeñas y medianas. La correlación para estimar el comportamiento fenológico a través de ambiente de crecimiento presentó en su mayoría coeficientes moderados r<0.5 sin diferencias estadísticas significativas (p>0.05); no fue así para la correlación entre altura de planta, donde presentaron correlación positiva fuerte: diámetro de copa, diámetro de raíz, peso total de planta húmeda y seca con valores r entre 0.7 y 0.8, (p<0.001). Se concluye que las plantas desarrolladas bajo irrigación el diámetro de tallo, raíz y copa; longitud de raíz, número de inflorescencias, flores y semillas; y peso seco total de planta fueron mayores que las de secano. La altura de planta en ambiente de secano e irrigación es la que mejor explica la correlación entre las variables fenológicas.

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Dr. Govindaiah Simuni
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Luai Farhan Zghair
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Hasan Ali Abed Al-Zu’bi
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Dr. Zafar Iqbal
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Dr. SHAHERA S.PATEL
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Dr. Ruchika Khanna
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Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
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DR. PATRICK D. CERNA
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Mexico
Dr. Mustafa Y. G. Younis
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DR. MUHAMMAD ISMAIL MOHMAND
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DR. MAHESH SHIVAJI CHAVAN
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DR. M. ARUNA
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Dr. Lim Gee Nee
Malaysia
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DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
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Iran
Dr. Achmad Choerudin
Indonesia
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Thi Mong Diep NGUYEN
France
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Oman
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Aseel Hadi Hamzah
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Anam Bhatti
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Md. Amir Hossain
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Ahmet İPEKÇİ
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