Levels of fsh, lh, shbg, total testosterone, and lh/fsh ratio in sudanese patients with polycystic ovary syndromein relation to body mass index

Objectives: to examine the role of PCOS in alteration of FSH, LH, Total testosterone, LH/FSH ratio as well as correlating the outcome to obesity. Methods: One Hundred female patients with PCOS based on Rotterdam 2003 criteria. Together with fifty healthy volunteer females included as controls. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), sex hormone binding globulin (SHBG) and total testosterone were tested in the two group. On top of that, we calculated LH/FSH ratio in all attendants. Body Mass Index (BMI) evaluated to be a part of the correlation. The resulted data were organized in tables and subjected for statistical analysis. Results: A significant increase was found in LH and total testosterone as well as significant decrease in SHBG in PCOS females compared to controls. Serum FSH was insignificantly increased in PCOS women. LH/FSH ratio was significantly high in non-obese patients when compared with obese patients and control. Conclusions: Hyperandrogenism is intrinsic to PCOS. At the same time, LH/FSH ratio was increased in non-obese PCOS patients.