18-F-FDG PET, PET/CT and MDCT in locally advanced colorectal cancer

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Author: 
Maria Grazia Caprio, Igino Simonetti, Luca Tarotto, Piero Trovato, Ciro Gabriele Mainolfi, Barbara Salvatore and Leonardo Pace
Subject Area: 
Health Sciences
Abstract: 

The aim of our study was to assess contrast enhanced multi-detector CT (CE-MDCT), FDG-PET and FDG-PET/CT accuracy in loco-regional staging of colorectal cancer. Methods: Eighteen (10 M, 8 F; aged 41-77 years) patients with histologically proven colorectal adenocarcinoma were enrolled. All patients underwent surgical resection within ten days of diagnostic assessment. CE-MDCT, FDG-PET and FDG-PET/CT were reviewed without knowledge of the results of histology. For each primary lesion a 3 point scale for characterization (1=benign, 2=indefinite, 3=malignant) and localization (1=uncertain, 2=probable, 3=certain) was used for FDG-PET and FDG-PET/CT. Sensitivity, specificity and accuracy were assessed for T staging for CE-MDCT and for N staging for CE-MDCT, FDG-PET and FDG-PET/CT. Results: 19 adenocarcinomas were identified at surgery (one patients had two synchronous lesions). Both CE-MDCT and FDG-PET/CT correctly identified and localized all lesions, while FDG-PEt alone identified all lesions, but only 14 of them (74%) were correctly localized. T stage was correctly identified by CE-MDCT in 17/19 lesions (90%). CE-MDCT correctly staged N parameter in 12/19 lesions (63%). On the other hand, FDG-PET correctly staged N parameter in 11/19 (58%) lesions, while FDG-PET/CT correctly staged N parameter in 16/19 (84%, p<0.05 vs PET) lesions. Overall, FDG-PET/CT showed higher sensitivity than FDG-PET and higher specificity than CE-MDCT in evaluating lymph-node involvement (p<0.05). Conclusion: These data suggest that fused FDG-PET/CT increases the accuracy of FDG-PET in localization of primary lesion and of both MDCT and FDG-PET in loco-regional N staging in patients with colon-rectal cancer.

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Editorial Board Member's

Dr.Geetanjali Joshi Mishra
Lucknow, UP, INDIA
Dr. Sankalp Verma
India
Tannu Arora
India
Prof Dr. Lee Mun Seng
Malaysia
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
Dr. Lim Gee Nee
Malaysia
DANA MOHAMMED
UK
Ali Majnoony Tootakhaneh
Iran
Prof. Somchai Amornyotin
Thailand
Omenna Emmanuel Chukwuma
Nigeria
Nurhodja Akbulaev
Turkey
Muhammad Hamid
Pakistan
MOHAMMAD GHOLAMI
Iran
MAVLYANOV ISKANDAR RAKHIMOVICH
Uzbekistan
Hasan Ali Abed Al-Zu’bi
Jordan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Eapen, Asha Sarah
USA
Dr. Ruchika Khanna
India
DR. MUHAMMAD ISMAIL MOHMAND
UK
DR. MAHESH SHIVAJI CHAVAN
India
Dr. Lokesh Gambhir
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Charu Bisaria
India
Dr. Achmad Choerudin
Indonesia
Bensafi Abd-El-Hamid
Algeria
Dr. Pralhad Kanhaiyalal Rahangdale
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Arun Kumar
India
DR. M. ARUNA
India
ALIIHSAN SEKERTEKIN
Turkey
Yassine KADMI
French
Tariqual Islam Sajeeb
Dhaka
Jiban Shrestha
Nepal
Fredrick OJIJA
Tanzanian
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Tarek Habeeb Ramadan Ahmed
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Moataz Mostafa El-Nahas Ali El-sherbini
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