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Anti-angiogenic and pro-apoptotic activity of aqueous extract of Leucas aspera in ehrlich ascites carcinoma model In vivo

Author: 
Kaythegowdanadoddi Srinivasa Balaji, Priyanka Shivaprakash, Malavalli Guruswamy Dileepkumar, Chakkere Shivamadhu Madhu, Basavaraju Puttalingaiah, Kagepura Thammaiah Chandrashekara and Shankar Jayarama
Subject Area: 
Life Sciences
Abstract: 

Angiogenesis is the creation of new blood vessels. The process of angiogenesis involves the migration, development, and differentiation of endothelial cells, which contour the inside wall of the blood vessels. The development of antiangiogenic agents to block new blood vessel growth will repress metastasis and encourage apoptosis of tumor. The present object focuses on phyto- constituents and antiangiogenic activity of the Leucas aspera leaves extract. Aqueous extract showed potent inhibitory activities against EAC cells procreation in in-vivo; this evidence shows that leaf extract of leucas aspera also has been showed anti- angiogenic activities. Aqueous extract steadily decreases the body weight & tumour volume when compare to control. Further, inhibition of blood vessels in intraperitoneum cavity of mice treated with Leucas aspera, which proves antiangiogenic activity. Chorioallantoic membrane assay (CAM) provides further evidence towards angiogenic inhibitory activity. Our coming up proposal is focusing in the direction is to enhancement of clincher based research and chemical characterisation of these compounds could further enhance the efficacy of this plant- based medicine in angiotherapy.

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