Anti-Microbial Studies Of Newly Synthesized Transition Metal Complexes Using Schiffbase Ligand (E)–N2–(Furan-2-Ylmethylene) Pyridine-2, 6-Diamine

Schiff bases and their complexes are versatile compounds synthesized from the condensation of an amino compound with carbonyl compounds and widely used for industrial purposes and also exhibit a broad range of biological activities including antifungal, antibacterial, antimalarial, antiproliferative, anti-inflammatory, antiviral, and antipyretic properties. Development of a new chemotherapeutic Schiff bases and their metal complexes is now attracting the attention of medicinal chemists. A novel schiffbase ligand is synthesized by aldehyde with Aromatic Amine to form Schiffbase ligand (L). It is mixed with 1stRow transition metal ions to form metal complexes. Complexes are characterized by Elemental analysis, UV- spectroscopy, Infrared spectroscopy and NMR. Elemental analysis of the metal complexes was suggested that the stoichiometry ratio is 1:2 (metal-ligand). The UVspectrum gives clear idea about the metal complexes. The Schiff base complexes have been screened for their invitro antibacterial activity against three bacteria via; (Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus sp.) also studied antifungal activities (Aspergillus Niger and Aspergillus flavus). Anti-oxidant properties of metal complexes also have been studied.