Antiarthritic potential of cleome gyndra leaves extract, in balb/c mice models

Background: Arthritis, leadingto pain and swelling of joints,is commonly treated using drugs or non-drug methods. But, an effective or permanent cure has not yet been achieved. Aim: Thus, this study aims at evaluating the anti-arthritic activity of Cleomegyndra (CG) in BALB/C Mice. Methodology: The toxicity of the plant extract was analysed, followed by the animal weights and antiarthritic activity of C. gyndrain mice, based on toxicity results. Results: The toxicity analysis revealed non-toxicity at 100 mg/kg, whereas 500 to 2000 mg/kg showed severe damagein multiple organs. Thus, Groups G1 to G5 were compared. G1 was control, G2 was the diseased group, G3, G4 and G5was disease induced and treated with 500 mg/kg,100 mg/kgand 50 mg/kg, respectively. The animal body weights showed that Groups G1 to G4 showed approximately similar weights, both before and after treatments. In contrast, G5 exhibited reduced weight in the mouse models after treatment than before treatment. This is attributed to the effect of arthritis, and the dose of CG being very low (50 mg/kg).The histopathological analysis of bone tissues showed that G1 showed no damage (arthritic score - 0) for bone and cartilage erosion, and synovial inflammation, where G2 exhibited severe damage (scores 2-3). G3 exhibited maximum effects (score - 1), G4 exhibited mild to moderate (score 1-2), andG5 exhibiteda moderate arthritic score of 2. Conclusion: The plant extract showed a dose-dependent anti-arthritic activity. Thus, the study recommends C. gyndra as a potential antiarthritic therapeutic.