CALL FOR PAPERS

CERTIFICATE

IMPACT FACTOR 2019

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

 

 

 

 

 

 

 

 

 

 

 

Antioxidant effect of ocimum gratissiumum linn. leaf against carbon tetrachloride (ccl4)-induced oxidative stress in wistar albino rats

Author: 
Okonkwo, C.J. and Njoku, O.U.
Subject Area: 
Life Sciences
Abstract: 

The leaves of Ocimum gratissimum (OG) were assayed for its phytochemical, vitamin and essential mineral content. Also, ethanol leaf extract of OG was investigated for antioxidant activity against carbon tetrachloride (CCl4)-induced oxidative stress in Wistar albino rats. Plasma lipid peroxidation inhibition and activities of the antioxidant enzymes, superoxide dismutase (SOD) and glutathaine peroxidase (GPx) were used as antioxidant indices, while Vitamin E (1000 IU, d-alpha-tocopheryl acetate soft-gel capsule) served as reference. Phytochemical analysis revealed the presence of Flavonoids, terpenoids, alkaloids and glycosides. The mean levels of zinc (Zn), manganese (Mn), copper (Cu) and iron (Fe) were 1.54, 6.16, 4.76 and 21.16 ppm, respectively, while those of beta-carotene, vitamins C and E were 0.222  0.02, 1.59  0.15 and 19.96  0.69 mg/100g. Result of the bioassay demonstrated that the CCl4-intoxicated rats were subjected to oxidative stress as indicated by low activities of their antioxidant enzymes; SOD (54.0  8 U/l), GPx (67254  1790 U/l) and high plasma lipid peroxidation index (61.86  4.09 µg/ml) when compared with normal control rats value of 202.5  23 U/l, 81497  1012 U/l and 48.78  8.04 µg/ml, respectively. The ethanol extract of O. gratissimum leaf reversed this situation as shown by the increased activity of the antioxidant enzymes and lipid peroxidation inhibition. The results indicated that ethanol extract of O. gratissium leaf significantly protected the rats from CCl4-induced oxidative stress. Furthermore, its antioxidant effect is dose-related.

PDF file: 

IJMCE RECOMMENDATION

ONLINE PAYPAL PAYMENT

CURRENT ISSUE

NEWS

CHIEF EDITOR
Rosane Cavalcante Fragoso, Brasil
ASSOCIATE CHIEF EDITOR

   

Jean-Marc SABATIER
Chief Scientific Officer and Head of a Research Group
France

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

 

 

 

 

 

 

 

 

 

 

 

EDITORIAL BOARD

Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran