The aim of this retrospective study was to assess selective factors affecting the reversibility of the ischemic heart. The methodology carried out based on cardiac study at stress and rest for the distribution of 99mTc-MIBI with consideration to age, weight and gender. The results revealed that: the uptake in cunt/second/pixel (c/s/p) in stressed cardiac study for the affected heart segment (ischemic segment) has been decreased as the age increases, indicating the aging is a negative factor for ischemic reversibility, while there was a significant (R2 = 0.8) increasing uptake during the stress phase for whole heart uptake, Rt/Lt lungs and the gastrointestinal tract (GIT). And there were significant (R2 = 0.7) decreasing uptakes by whole heart, GIT and Rt/Lt lungs as the age increases with superior significant uptake by GIT during stress and rest at R2 = 0.6 and 0.5 respectively. And in the correlation between weights in Kg versus count/sec at stressed cardiac study, the analysis revealed significant increased uptakes by GIT, Rt lung, Lt lung, and whole heart (R2 ≈ 0.6) as the weight increases whereas the same organs (GIT, Lt lung, Rt lung and the whole heart) showing significant (R2 ≈ 0.7) decreasing uptake as the weight increases as well as the affected heart segment The study also showed there were high frequencies percent of obese and overweight patients 52% and 32% respectively with ischemic heart segment reversibility of 37% among female relative to 30% among male, while the irreversible cases were greater among male 15% relative to only 4% among female and the incidence % of IHD is predominant among male 55% compared with 45% among female. The stress cardiac study enhance the uptake by the reversible ischemic segment hence gives further knowledge about ischemic reversibility% that could be managed by simple medications.