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Association of cdh13 (rs7200009) gene polymorphism with essential hypertension in south Indian population

Author: 
Vijayashree Priyadharsini Jayaseelan, Karthikeyan Muthusamy, Shridevi Venkataramani, Paramasivam Arumugam, Jayaraman Gopalswamy and Santhiya Sathiyavedu Thiagarajan
Subject Area: 
Life Sciences
Abstract: 

Hypertension (HT) is the most prevalent, complex quantitative trait which is characterized by chronic increase in the blood pressure. High blood pressure is one of the known risk factor for stroke, coronary artery disease, congestive heart failure, end-stage renal and cerebrovascular disease. Essential hypertension (EH) is the most common condition which contributes to ~ 95% of cases and has no clear single identifiable cause. Monogenic forms of hypertension, familial studies, twin studies and cross transplantational studies in experimental models have revealed the association of genetic components with essential hypertension. In view of this fact a case-control association study was conducted to investigate the possible involvement of CDH13 (rs7200009) polymorphism in essential hypertensive patients. A total of 568 cases and 604 controls were recruited for this study. The SNP marker of CDH13 gene (rs7200009) showed significant difference between the case and control groups in south Indian population studied. The genotype frequency was almost the same for both the case and control data sets. The result of the present study indicates that CDH13 gene polymorphism (rs7200009) is associated with essential hypertension in south Indian population.

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