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Association of low grade chronic inflammation and activated innate immune system in pathogenesis of newly diagnosed type 2 diabetic patients as well as patients under treatment by oral hypoglycemic drug for minimum 5 yrs

Author: 
Shamim Shaikh Mohiuddin
Subject Area: 
Health Sciences
Abstract: 

Aim: Pathogenesis of type 2 diabetes is observed to be associated closely with acute phase response which is predominately cytokine-mediated. By estimating circulating acute phase proteins in type 2 (T-2) diabetic patients, I tried to establish this hypothesis. Method: Newly diagnosed 25 T-2 cases and 25 T-2 cases under oral hypoglycemic agent for at least 5 years were chosen and were estimated the level of α1- antitrypsin, α1- acid glycoprotein, ceruloplasmin and fibrinogen. These all parameters are well known acute phase reactants and very important tools for diagnosis for low grade chronic inflammatory reaction. Thirty normal controls were also studied. The levels of these proteins were correlated with their random plasma glucose values and BMI. Results: In the T-2 patients (p<.00001) in comparison with the controls, the values of all the four proteins studied were significantly elevated. Conclusion: By the above results and findings is can be definitely postulated that a low grade inflammatory process is associated in the pathogenesis of type 2 diabetes. This can be further explored for diagnosis, management and follow up.

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