Emblica officinalis (amla), a cornerstone of traditional medicine, is widely recognized for its potent antioxidant profile, encompassing polyphenols, flavonoids, tannins, gallic acid, and ellagic acid. These bioactive compounds confer multiple health benefits, including hepatoprotection, cardio protection, anti-inflammatory, and anti-aging effects. However, conventional formulations often suffer fromattenuated bioavailability, poor solubility, rapid metabolic degradation, and instability of phytoconstituents, which limit their therapeutic efficacy. This review systematically examines the challenges associated with traditional medicinal formulations of Emblica officinalis and highlights the advances offered by nanotechnology-based delivery systems. Key nanocarrier approaches—including nanoparticles, liposomes, Nanoemulsions, and polymeric matrices—are discussed in relation to their ability to enhance solubility, stability, targeted delivery, and sustained release of amla-derived antioxidants. The narrative integrates pharmacological evidence, formulation strategies, and mechanistic insights to provide a comprehensive understanding of how nano formulation can overcome conventional limitations. Furthermore, the review outlines current gaps, safety considerations, and future research directions for translating nano-enhanced amla formulations into clinical and nutraceutical applications. By bridging traditional herbal medicine with modern nanotechnological innovation, this review underscores the relevance of advanced delivery strategies in maximizing the therapeutic potential of Emblica officinalis, thereby offering a valuable framework for researchers, formulators, and healthcare practitioners.
