Thalassemia is a genetically passed down blood disorder in which body makes an abnormal form of haemoglobin that leads to anaemia, several organ failure due to iron overload and even death. Disease similar to Thalassemia is not described in Ayurveda, but on the bases of conceptual understanding through Ayurveda concepts it concludes that Thalassemia may be correlated with Beejadoshjanya, Adibalapravruta and Sahaja Vyadhi and nomenclature was coined as Beejadushtijanya Pandu. It can be understood that Pittapradhana Tridosha affects the functions of Raktadhatu. Some of main effective drugs like Devdaru, Agatsya, Kumari, Rohitaka, Agnimantha which was also given in Ayurveda taxies were added in Musta Triphaladi avaleha. Other medicine Gandhakadi Yoga is suggested for Lohasevanajanya vikaraprashamana (iron overloading management). Present study is a Case study on 7 year old male child who have been diagnosed Thalassemia major. His complaint was that severe anemia he is on regular blood transfusion every 20-20 days, liver and spleen enlarged and the serum iron and serum ferritin values were above normal limits according to investigation. At the end of three months of Ayurveda therapy as adjuvant, his blood report and the symptoms of the disease showed very promising results.