Bisphosphonate-related femur fractures: operative and nonoperative management outcomes

Several case series have discussed the outcomes of the operative management of AFFs. Weil et al reviewed clinical data from 15 patients with 17 AFFs associated with long-term BP use who were treated surgically. Fracture healing after the initial procedure among patients treated with intramedullary nails was 54%, with 46% of patients requiring reoperation. The authors attributed this high failure rate to qualitative bone defects caused by long-term BP use.