Lipoleiomyoma of the uterus is uncommon benign uterine tumour in premenopausal and postmenopausal women. The exact etiology is not known, but it may be associated with a history of leiomyoma, obesity, and hyper-estrogenic disorders. There are several proposed theories for the pathogenicity of lipoleiomyoma, none of which has been proven yet. Here we report a case of uterine lipoleiomyoma in a postmenopausal woman with long-standing diabetes mellitus and hypercholesterolemia. This observation suggests that coexistence of both diabetes mellitus and hypercholesterolemia in this patient may be just a syndromic association or it may have a role in the mechanism behind changes of leiomyoma to lipoleiomyoma in postmenauposal women.
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