In the age of globalization, adolescent girls often struggle with certain specific challenges not experienced beforehand. Issues such as gender discrimination, eve teasing, alcoholism, drug abuse, trafficking, early marriage, adolescent pregnancy, rape and cybercrimes are quite rampant today. In order to understand various challenges of adolescent girls a study was conducted among the sample of 600 adolescent girls from 15 schools of Malappuram district in the state of Kerala. Analysis of the present study reveals that adolescent girls face many challenges related to gender role perception, conflict of emotions, safety issues, lack of role models, peer pressures, confusions regarding inter personal relationship, accepting bodily changes, menstrual hygiene and reproductive health, curiosity regarding sex and sexuality, choice of career, educational aspirations, gender discrimination and usage of ICT. Among these, safety issue is the most pertinent challenge faced by girls and other challenges follow them. The study highlighted the need to think about long term action plans with a feminist perspective for addressing these challenges with cooperation from every segment of the society.