Correlation of duration of diabetes mellitus and sex specific distribution as a risk factor for prognosis of covid-19

To know whether duration of diabetes is a risk factor influencing the progression and prognosis of novel coronavirus disease (COVID-19).Material and Methods: A total 96 consecutive patients confirmed with COVID-19 with diabetes mellitus were studied in MGM Medical College and Hospital. Demographic data, medical history, symptoms and signs, laboratory findings, chest computed tomography (CT) as well the treatment measures were collected and analysed. Results: We found that majority of cases with COVID-19 and diabetes mellitus were more between age group of 31 to 40 (n = 29). Male to female ratio was 1.5:1. Patients having duration of Diabetes mellitus of more than 10 years were having bad prognosis. (1% Surived ).These patients were at higher risk of severe pneumonia, release of tissue injuryrelated enzymes, excessive uncontrolled inflammation responses and hypercoagulable state associated with dysregulation of glucose metabolism. Furthermore, serum levels of inflammation-related biomarker such as D-dimer, were significantly higher (P < .01) in diabetic patients compared with those without, suggesting that patients with diabetes are more susceptible to an inflammatory storm eventually leading to rapid deterioration of COVID-19. Conclusions: Our data supports the notion that duration of diabetes mellitus and sex specific distribution should be considered as a risk factor for a rapid progression and bad prognosis of COVID-19. More intensive attention should be paid to male patients with diabetes mellitus with long duration and having COVID-19