Implant therapy currently promises a good, long-term treatment result without impacting health; however, its success depends on many factors. Titanium isthe most widely used inert bio-material for dental implants due to its excellent mechanical strength and biocompatibility. But in some cases there are reports of problems caused by titanium like corrosion, biofilm formation ,Titanium-induced hypersensitivity which can lead on to implant rejection. To avoid hypersensitive reactions to metallic dental implants, precautionary principles for primary prevention should be established.For medical purposes, it is important to define and discuss the characteristics of metals used in implantable devices and to ensure their biocompatibility.