Situs Inversus Totalis is a rare condition with not much known sex discrimination. The cause for the same is still unknown although some studies describes certain maternal medical conditions like diabetes mellitus as a reason. The term Situs Inversus is a short form of the later meaning inverted position of internal organs. Such individuals are generally asymptomatic and have a normal life expectancy and it may go unnoticed for a long period of lifetime. Other congenital abnormalities can also be seen with this condition like cardiac defects, pulmonary infections. Being a rarecondition, the literature for it is not that extensive. In our report we describe a case of Dextrocardia with SitusInversus Totalis in a newborn with respiratory distress.