The article present clinical sings, diagnosis and successful treatment of trypanosomosis in crossbred jersey cow presented to veterinary dispensary in Rasipuram, Tamilnadu. Clinical examination revealed high fever (105ºF), pale mucous membrane, diarrhoea, with the history of anorexia, dullness, excess salivation, dyspnoea, ocular discharges. Blood smear examination revealed presence of Trypanosome evansi in the peripheral blood. The cow was treated with single dose of inj. Diminazenediaceturate (Berenil) @ dose rate of 3.5 mg/kg B.W and Oxytetracycline @ dose rate of 22 mg/kg B.W along with supportive therapy for three days. The cow responded well and recovered uneventfully.
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