The textile industry is searching for innovative production techniques to improve the product quality. Nowadays, Micro fibers have set new trends in the textile industry and manmade fibers were upgraded to be superior to natural fibers both in appearance and also in the other physical and comfort properties. The blending of the micro denier polyester fibre along with cotton fibre is a popular one for research and it gives valuable performance with the main component fibre properties and additional micro polyester fibre properties. The research work shows that the part of micro polyester fibres improves the fabric properties in the aspects of better drape, softness, shrink resistance, high strength and good insulation against atmosphere conditions, good absorbency, good wicking property, good air permeability and environment friendly. This paper deals with the study of surface modification of 100% micro denier polyester, 100% cotton and 65/35 micro polyester / cotton fabrics by plasma treatment. The various properties improvement in the above fabrics was discussed and conclusion was made based on the performance of plasma treatment on the subjected fabrics.