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Effect of vitamin c on serum lipid profile in normal human subjects: A study

Author: 
Gaur, G.S. and Dixit, A.K.
Subject Area: 
Health Sciences
Abstract: 

Vitamin C is one of the most important antioxidants that inhibits lipid peroxidation and improves endothelial function. This study aims to assess the effects of vitamin C supplementation on lipid profiles and as markers of lipid peroxidation among normal humans. A total of 50 healthy individuals were selected, instructed and given the understanding of the purpose of study. The test group comprising 25 individuals were given 500mg Vitamin C tablets one daily for 30 days and control group of 25 individuals were given placebo capsules(Glucose 500mg) one daily for 30 days. Fasting blood samples were collected in the morning for estimation of cholesterol, triglycerides, HDL-C, LDL-C and VLDL-C on first day, second blood samples were taken after thirty days of supplementation and same estimations were carried out. After supplementation with vitamin C, serum vitamin C levels increased significantly in the test group as compared to control group (p<0.05). There was a highly significant decrease in serum cholesterol levels in test group as compared to placebo group (p<0.001). However, decrease in serum LDL-C levels was also significant in test group as compared to placebo group (p<0.02). But there was a insignificant difference in serum levels of total triglyceride, HDL-C and VLDL-C (p>0.05). Conclusion: Supplementation with 500 mg vitamin C decreases cholesterol and LDL-C and improves lipid profiles. But have no statistically significant effect on VLDL-C, HDL-C and triglycerides. The study suggests the need for a prolonged vitamin C supplementation which is also an important constituent of the antioxidant system.

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