Present investigated was performed to study the toxic effects of oral administration of silver nanoparticles on liver and serum parameters of male rat. Six healthy Wistar rats weighing between 150-200 g were randomly selected and divided into three groups. Group I serve as control group and received distilled water while treatment groups were administered 1 mg kg–1 b.wt. silver nanoparticles (AgNPs) for 30 days. After 24 hrs of experiments completion, rats were sacrificed using diethyl ether. Blood was collected by cardiac puncture to extract out serum for biochemical estimation. Liver was excised and used for histopathological examination. Exposure of AgNPs results in significant alteration in levels in ALT, AST, ALP, bilirubin and acid phosphatase. The histopathological examination of liver revealed congestion, inflammation and cellular damage due to exposure to the AgNPs. Thus it can be concluded that silver nanoparticles at dose level 1 mg kg–1 b.wt could be harmful if exposed for month which proven by serum biochemical and histopathological alterations in liver.
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