Present study deals with Ethno botanical investigations among rural population in Marathwada. Marathwada region comprising seven districts, Aurangabad, Beed, Jalna, Latur, Nanded, Osmanabad and Parbhani form a part of Vast Deccan Plateau of India, located 7005 – 780 E longitude and 1705 - 2005 N longitude An ethno botanical investigations has been carried out to record the indigenous knowledge of the ethnic communities of Marathwada. Marathwada have good association with plant resources. Authors have collected the information, for this authors visited villages such as Ambajogai, Parli-Vaijnath, Degloor, Nanded, Mahur, Daheli, Saradgaon, Kakhandi, Loha, Loni , Kinwat, Anandwadi etc. Photos of local in habitants (medicinal men) also taken. The aim of study to disseminate this knowledge for benefit of poor people, as plants are easily available locally and utilized by local healers in day today life. So it must be preserved and propagated