This study has been conducted with the main aim of exploring the rural entrepreneurship practices and rural small business owners’ entrepreneurial orientation. Hence the study has collected both qualitative and quantitative data in three were das (districts), selected out of 31 rural were das of tigray region. The study has followed a survey research design with both quantitative and qualitative approaches in which it has been adopted econometrics analysis. The study also follows a cross-sectional research design so as to triangulate the findings of different approaches in an effort to provide greater confidence to the study. Based on the findings, entrepreneurs prefer to take moderate risks in situations where they have some degree of control or skill in realizing a profit. Moreover as compared to those who acquire their business by rent those who inherited have low willingness to take risk. Education significantly affects entrepreneurial decision making in which Entrepreneurs with strong educational status makes decision quickly. Enlarging education and career preparation to increase creating and growing businesses is potentially a powerful way to hold young people in rural communities. It also paves new opportunities for dependent employees in trades and other professions