The expression of matrix metalloproteinase-9 (mmp-9) and ki-67 labeling index in intracranial astrocytoma patients at haji adam malik general hospital medan 2017

Introduction: Astrocytoma is one of neuroepithelial tumor and these tumors are graded in four scale based on the aggresiveness. Overexpressions of MMP-9 has been correlated to tumor’s progresivity, poor prognostic and predictive marker in cancer, while Ki-67 is strongly associated with cell proliferation. Method: This study is being conducted to analyze the correlations between MMP-9 expressions and KI-67 in intracranial astrocytoma. This reprospective study is using cross-sectional method. The expression of MMP-9 and Ki-67 was evaluated, as well as its prognostoc value. The study is held at Haji Adam Malik General Hospital, Medan, North Sumatera with total samples of 19. Results: There is no significant correlation in astrocytoma classification with MMP-9 and Ki-67 Li expression (p=1,000). There is no significant correlation of MMP-9 overexpression with in mortality (p=0.117) however there is significant correlation of Ki-67 Li with mortality (p=0,005). Conclusion: There is no significant association between MMP-9 and Ki-67 Labeling Index in intracranial astrocytoma.