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Familial split-hand/foot malformation: (Lobster claw anomaly)
Subject Area:
Health Sciences
Abstract:
Split Hand/split-Foot Malformation (SHFM) is a congenital anomaly with failure of development of the central digital rays of hand or foot to a variable extent. It is characterized by hypoplasia/aplasia of the phalanges, toes, metacarpals and metatarsals. The presentation may be an isolated anomaly or may be associated with syndrome and thus have variable pattern of inheritance. SHFM may occur as an isolated entity or as part of a syndrome. Both forms are frequently found in association with chromosomal rearrangements such as deletions or translocations.
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