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Giant cell fibroma (GCF) is an extremely rare histopathological entity characterized by uninucleated or multinucleated giant fibroblasts subepithelially, representing 0.4 - 1% of total biopsies. Etiology is unknown and there are various controversies regarding origin of giant multinucleated fibroblasts. It clinically presents as an asymptomatic, pedunculated or sessile growth less than 1 cm in size. A 30 year old male patient reported with a small growth over the tip of the tongue. Intra-oral examination revealed a solitary, pinkish-white firm growth with a sessile base, was firm and fibrous in consistency. A clinical diagnosis of fibroma was given and excisional biopsy was done. Histopathological examination revealed long and slender rete ridges. The underlying connective tissue consisted of dense collagen bundles with large multinucleated stellate shaped fibroblasts subepithelially. Based on the microscopic findings a final diagnosis of a giant cell fibroma was made. This case is reported for its rare occurrence.
Rosane Cavalcante Fragoso, Brasil
Chief Scientific Officer and Head of a Research Group
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