Introduction: Appendicitis is one of the commonest surgical emergency and appendectomy is the most common surgery. Histopathological examination of appendectomy specimens is must to confirm the diagnosis and also to report unusual findings and to detect incidental neoplasms at the earliest possible Aims and Objectives: To study the proportion of various lesions in resected specimens of appendix and to emphasize the need of histopathological examination. Material and Methods: A retrospective study including 761 appendectomy specimens over a time period of 2 yrs from October 2014 to September 2016 was conducted. Result: In our study, males are more as compared to females with sex ratio of 2.23:1. Maximum number of cases belong to age group 20-30 followed by 10-20 years. Most common finding is the inflammatory lesions accounting to 91.06%. Negative appendicectomy and incidental appendicectomy rates are 4.73% and 3.67% respectively. 10 cases (1.31%) showed benign and malignant neoplasm. Carcinoid is the most common malignancy (0.52%). Conclusion: This study showed a marked variations in morphological spectrum and also some incidental neoplastic and rare lesions hence emphasizing the need of histopathological examination.