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Hormonal induction of benign prostatic hyperplasia in rats: effects on serum macromolecular metabolism

Author: 
Chukwunonso ECC EJIKE and Lawrence US EZEANYIKA
Subject Area: 
Physical Sciences and Engineering
Abstract: 

Benign prostatic hyperplasia (BPH) was induced in rats using a mixture of dihydrotestosterone (DHT) and estradiol valerate (ratio 10:1). The fasting blood glucose levels, serum lipid profile and pro-atherogenic indices of the rats were estimated using standard procedures, and compared to those of rats in a control group. The results show that rats in the test group had significantly (p<0.05) lower fasting blood glucose and serum total cholesterol levels, while the other lipid and lipoprotein parameters and serum lipid pro-atherogenic indices were similar (p>0.05) in both groups. Though BPH is thought to be related to metabolic derangements, it appears that BPH can be induced without a collateral disruption of serum macromolecular metabolism.

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