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Immunohistochemical detection of epstein - barr virus in nasopharyngeal carcinoma lesions among Sudanese patients using lmp-1 monoclonal antibody

Author:

Monawar M Abdalazez, Mohammed A Abdallah, Esam M AbdulRaheem, Ibrahim B Yousif and Ashwag M Mukhtar

Subject Area:

Health Sciences

Abstract:

Objective: this was a retrospective descriptive study aimed to assess the role of latent membrane protein-1 (LMP-1) Monoclonal Antibody in the detection of Epstein- Barr virus (EBV) in nasopharyngeal carcinoma (NPC) lesions in Sudanese patients. Methods: Forty-five paraffin-embedded formalin-fixed tissue sections of nasopharyngeal carcinoma lesions were stained by Anti- EBV LMP-1 and results were correlated with the available clinical data. Results: EBV was positive in 23 cases and negative in 22 cases. Most positive results were in elderly males with undifferentiated carcinomas. Conclusion: Anti- EBV LMP-1 is effective in detecting EBV in nasopharyngeal carcinoma lesions.

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