A wide variety of normal and neoplastic human tissues are characterized by granular cells. Granular cell lesions from many different sites share similar light and electron microscopic features. The striking histological feature is the morphological resemblance of the cells in these lesions which are characterized primarily by the presence of numerous cytoplasmic acidophilic granules. The entire tumor may be composed of these cells or the cells may be seen as focal aggregates. Odontogenic tumors of the jaws with a predominant component of granular cells are exceedingly rare. This presentation highlights the occurrence of granular cells of both epithelial and mesenchymal origin in odontogenic tumors of varying clinical behaviour, treatment and prognosis.
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