CERTIFICATE

IMPACT FACTOR 2021

Subject Area

  • Life Sciences / Biology
  • Architecture / Building Management
  • Asian Studies
  • Business & Management
  • Chemistry
  • Computer Science
  • Economics & Finance
  • Engineering / Acoustics
  • Environmental Science
  • Agricultural Sciences
  • Pharmaceutical Sciences
  • General Sciences
  • Materials Science
  • Mathematics
  • Medicine
  • Nanotechnology & Nanoscience
  • Nonlinear Science
  • Chaos & Dynamical Systems
  • Physics
  • Social Sciences & Humanities

Why Us? >>

  • Open Access
  • Peer Reviewed
  • Rapid Publication
  • Life time hosting
  • Free promotion service
  • Free indexing service
  • More citations
  • Search engine friendly

Impact Of Experimental Hyperglycemia On The Sciatic Nerve Of Albino Rats - A Histological And Histomorphometric Study

Author: 
Dr. Muhamed Faizal and Dr. Aijaz Ahmed Khan
Subject Area: 
Health Sciences
Abstract: 

The complications of chronic diabetes affect many systems including the nervous system wherein the peripheral neuropathy is the most common presenting feature and which if not controlled may necessitate limb amputation. Since the exact mechanism of hyperglycemia-induced peripheral neuropathy and its treatment are not completely known, the present study was aimed at an effort to further the information in this regard. After ethical clearance, 36 animals were divided into six groups having six rats each. The groups consisted of age-matched controls and experimental groups of two weeks, one month, two months, four months and six months duration of diabetes. Diabetes was induced by a single dose of streptozotocin (60 mg/kg, intraperitoneal). At the end of each experimental period, animals were euthanized and perfusion fixed with Karnovsky’s fixative. The blood serum was subjected to biochemical analysis and the sciatic nerve tissue blocks were processed for paraffin sectioning, routine and special staining for light microscopy. Biochemical, histomorphological findings and histopathological features revealed that the prolonged duration of hyperglycemia resulted in the raised serum creatinine, lowered serum total protein, reduction of myelinated fibers and remarkable thickening of endoneurial, perineurial and epineurial collagen. It is concluded that the biochemical alterations, change in the ratio of myelinated fibers and heaping up of collagen fibers at every level of organization appear to be important contributing factors for the deterioration of peripheral nerve functions in chronic diabetes.

PDF file: 

ONLINE PAYPAL PAYMENT

IJMCE RECOMMENDATION

Advantages of IJCR

  • Rapid Publishing
  • Professional publishing practices
  • Indexing in leading database
  • High level of citation
  • High Qualitiy reader base
  • High level author suport

Plagiarism Detection

IJCR is following an instant policy on rejection those received papers with plagiarism rate of more than 20%. So, All of authors and contributors must check their papers before submission to making assurance of following our anti-plagiarism policies.

 

EDITORIAL BOARD

Dr. Swamy KRM
India
Dr. Abdul Hannan A.M.S
Saudi Arabia.
Luai Farhan Zghair
Iraq
Hasan Ali Abed Al-Zu’bi
Jordanian
Fredrick OJIJA
Tanzanian
Firuza M. Tursunkhodjaeva
Uzbekistan
Faraz Ahmed Farooqi
Saudi Arabia
Eric Randy Reyes Politud
Philippines
Elsadig Gasoom FadelAlla Elbashir
Sudan
Eapen, Asha Sarah
United State
Dr.Arun Kumar A
India
Dr. Zafar Iqbal
Pakistan
Dr. SHAHERA S.PATEL
India
Dr. Ruchika Khanna
India
Dr. Recep TAS
Turkey
Dr. Rasha Ali Eldeeb
Egypt
Dr. Pralhad Kanhaiyalal Rahangdale
India
DR. PATRICK D. CERNA
Philippines
Dr. Nicolas Padilla- Raygoza
Mexico
Dr. Mustafa Y. G. Younis
Libiya
Dr. Muhammad shoaib Ahmedani
Saudi Arabia
DR. MUHAMMAD ISMAIL MOHMAND
United State
DR. MAHESH SHIVAJI CHAVAN
India
DR. M. ARUNA
India
Dr. Lim Gee Nee
Malaysia
Dr. Jatinder Pal Singh Chawla
India
DR. IRAM BOKHARI
Pakistan
Dr. FARHAT NAZ RAHMAN
Pakistan
Dr. Devendra kumar Gupta
India
Dr. ASHWANI KUMAR DUBEY
India
Dr. Ali Seidi
Iran
Dr. Achmad Choerudin
Indonesia
Dr Ashok Kumar Verma
India
Thi Mong Diep NGUYEN
France
Dr. Muhammad Akram
Pakistan
Dr. Imran Azad
Oman
Dr. Meenakshi Malik
India
Aseel Hadi Hamzah
Iraq
Anam Bhatti
Malaysia
Md. Amir Hossain
Bangladesh
Ahmet İPEKÇİ
Turkey
Mirzadi Gohari
Iran