Induced effect of lambda cyhalothrin on biochemical parameters of protein metabolism in selected tissues of albino mice

Pyrethroids are synthetic chemical analogues of pyrethrins, which are naturally occurring insecticidal compounds produced in the flowers of chrysanthemums (Chrysanthemum cinerariaefolium). Lambda-cyhalothrin is a pyrethroid insecticide. Insecticidal products containing pyrethroids have been widely used to control insect pests in agriculture, public health, and homes and gardens. With regard to effectiveness and toxicity, this compound appears to be the first-choice insecticide used than organochlorines, organophosphates and carbamates. It is highly used in the cotton plantation, in vegetable production and to control a wide range of insect pests in a variety of crops. The present study is aimed to evaluate the effect of Lambda cyhalothrin on biochemical parameters such as Total Proteins, FAA, Protease, GDH, Ammonia and Urea in selected tissues Intestine and Testis. To assess the effect of Lambda-cyhalothrin, mice were gavaged orally for 10, 20 and 30 consecutive days with sub lethal doses of Lambda (1/5th of LD50 4.8 mg/kg bw). This caused significant decrease in total proteins and increase in FAA, protease, glutamate dehydrogenase, ammonia and urea in Intestine and Testis when compared to the controls.