Background: Some factors which cause nurses’ intense turnover are organizational commitment and satisfaction. Nurses who have low commitment will withdraw from an organization and will eventually retire from the hospital. Likewise it is with job satisfaction where the feel dissatisfied with their job tend to leave an organization. When the condition of dissatisfaction continues, they will leave the organization. Aims: to find out the influence of organizational commitment and job satisfaction on nurses’turnover intention at Malahayati Islamic Hospital, Medan. Methods: The research used causality design. The population in this study were all nurses at the Malahayati Islamic Hospital in Medan, namely 160 people. The sample size was determined using the power analysis method and obtained a sample of 126 people. The sampling technique used proportional random sampling. The data were analyzed by using descriptive analysis and multiple linear regression analysis. Results: The result of the research showed that the most dominant organizational commitment of nurses was affective commitment of 40 people (31.8%) and the strength of these commitments was mostly in the moderate category as many as 71 people (56.3%), quite satisfied as many as 59 of them (46.8%) and had moderate turnover intention of 52 of them (41.3%).It was also found that, partially, there was negative and significant influence organizational commitment on nurses’ turnover intention at p-value = 0.00 < 0.05, and there was negative and significant influence of organizational commitment and job satisfaction on nurses’ turnover intention simultaneously at p-value = 0.00 < 0.05. Conclusion: It is expected that hospital management can improve organizational commitment by increasing nurse affective, continuance, and normative commitment. Furthermore, management must also increase nurse job satisfaction through increasing nurse satisfaction with satisfaction with salary and remuneration, recognition and promotion and work conditions.