Purpose: To determine the knowledge, self-efficacy and breast cancer screening practices of Primary Health Care Nurses (PHCNs)in SVG. The effects of interpersonal and situational influences on PHCNs’ participation in breast screening activities were also examined. Methods: This study utilized a non-experimental, descriptive survey design. Quota proportionate sampling was used to select 62 PHC Nurses working in the 9 health districts of SVG. The instrument consisted of researchers’-developed questionnaire consisting primarily of objective-type items which assessed knowledge of breast cancer, self-efficacy and breast cancer screening practices. Microsoft Excel 2007 and IBM PASW (SPSS) Version 22 were used to determine and confirm the results of this study. Findings: With 62 of the targeted 70 nurses responding, PHC nurses had poor knowledge of breast cancer. There was no statistically significant relationship between levels of awareness of breast cancer and respondents’ age, experience or professional qualification. Implications for practice: Continuous education and training are required to increase nurses’ levels of awareness of breast cancer. Organizational support and policies are essential in ensuring consistency and standardization of breast cancer screening practices. Replication of this study will provide greater insight into the phenomenon.