Bladder cancer (BC) is one of the most widespread cancers distressing men and women and thus has a philosophical impact on health care. Free radicals lead to lipid peroxidation which is destructive in nature and has been suggested to play a role in cancers. Aims and Objectives: To determine the role oxidative stress and level of antioxidants in bladder cancer (BC) by estimation the expression of Hexanoyl-ysine (HEL) as lipid peroxidation marker in cancerous tissue of bladder and total antioxidants capacity (TAC)in serum of bladder cancer. Material and Methods: In present study 50 patients with bladder cancer, 18 non –cancer subjects as control aged between (31-85) years were enrolled. The diagnosis of patients was confirmed by a pathologist in the hospital referred to above according to WHO/ISUP grading system (MacLennan et al., 2007). Serum was analyzed for total antioxidants capacity (TAC) using ELISA, tissue was analyzed for expression of lipid peroxidation marker (HEL) using immunohis to chemistry ( IHC). Results: Serum TAC levels were significantly lower (P<0.0001) in bladder cancer patients as compared to control. The finding of IHC showed a highly significant difference (p< 0.0001) in the mean of immunore activity score of HEL when compared to that of controls. Conclusion: Increased levels of lipid peroxidation product (HEL) and depletion of total antioxidants capacity in patients with bladder cancer may suggest that oxidative stress plays a key role in the genesis of bladder cancer.
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