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Liposomes used as novel targeted drug delivery system for cancer treatment

Author: 
Sandeep Kumar Maurya and Divya Jaiswal
Subject Area: 
Life Sciences
Abstract: 

Purpose of Review: In this review paper, we highlight the recent concepts and discuss some of the current advances and future prospects used in cancer therapy. We hereby use the nanoparticle based such as liposome preparation for targeting the cancer. Methods used for Review: We performed a non-systematic search of journals, authoritative guidelines such as WHO, NCBI, etc. and selected the most comprehensive and relevant research articles, clinical studies, translational articles and review articles on nanoparticle such as liposome-based cancer therapy. The selection of paper for the reviewing purposes are purely based on the originality of the paper as well as by observing the clinical uses. Recent Findings in Review: Cancer is a major public health problem worldwide. Systemic delivery of free drug is considered a major clinical failure of chemotherapy in cancer treatment, as limited concentration of the drug reaches at the tumor site which is site of action for the drug. Most active pharmaceutical ingredients (APIs) used in chemotherapy are highly cytotoxic to both type of cells i.e., cancerous cells and normal cells. According to this, targeting tumor vasculature is essential for tumor therapy. In this context (reference), the encapsulation of anticancer drugs in a nanoparticle i.e., liposomal system offers safe platforms for the targeted delivery of anticancer drugs for cancer therapy. This may also be helpful and useful for reducing the cytotoxic side effects of anticancer drugs on normal cells. This short review focuses on the use of liposomes in anticancer drug delivery, different liposomal formulations for cancer, and the mechanism of action of liposomal drug delivery for cancer therapy and some of the recent finding bioactive compound used in liposomal form for the cancer treatment.

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