Endodontic treatment of non-vital immature permanent teeth are a challenge itself, because of the size of the canal, the thin and fragile dentine walls and large open apex. The challenge has been faced by different treatment options like apicoectomy, apexification, regenerative and revascularization endodontics. The aim of the present article is to report three clinical cases of management of non-vital immature permanent teeth by using different treatment protocols. Child Patient with an age range of 8-10 yrs reported with a common chief complaint of pain. The clinical and radiographic examination revealed carious teeth with open apex in respect to 46 (2 cases) & Ellis class III fracture with open apex in 21(1case). Three different treatment plans were deviced for them. First case done by apexification using Ca(OH)2, Second case, done by MTA apexification & Third case, done by MTA apexification guided by PRF matrix. Apexification done by the discussed procedure have good success rate. The technique was selected depending upon the situation.