What is sound medical practice? The way in which this question is answered will depend in large part on which root metaphor is selected to underscore a particular medical practice. Medical knowledge, like all knowledge, is built around three root metaphors—mechanism, organism, and spiritualism (or mind). These root metaphors, in turn, have given rise to what may be called guiding metaphors. In medicine these three guiding metaphors are—the war on disease, the pursuit of optimal health, and the quest for wholeness. The objective of medicine is to help humanity to live longer, healthier, and happier lives. What choices can we make for ourselves to promote our personal well being?