During routine cadaver dissection of dorsal aspect of hand of 54 and 60 years of male, multiple tendons of Extensor Pollicis Brevis (EPB) were found on right and left side respectively. On the other side EPB maintained the normal anatomy. Variations in muscles of thumb have always attracted hand surgeons as they can be used for tendon transfer. Surgery and physiotherapy point of view multiple tendons of EPB are important. The clinical significance and embryological basis of multiple tendons of EPB is discussed.